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结肠间置移植治疗腐蚀性食管狭窄:中期功能结果

Colon interposition graft for corrosive esophageal stricture: midterm functional outcome.

作者信息

Ezemba Ndubueze, Eze John C, Nwafor Ikechukwu A, Etukokwu Kenneth C, Orakwe Obinna I

机构信息

Division of Cardiothoracic Surgery, National Cardiothoracic Center, University of Nigeria Teaching Hospital, Ituku-Ozalla, PMB 01129, Enugu, 400001, Nigeria,

出版信息

World J Surg. 2014 Sep;38(9):2352-7. doi: 10.1007/s00268-014-2574-3.

Abstract

BACKGROUND

Corrosive esophageal stricture is a major cause of morbidity among Nigerians. In most cases, this follows accidental or parasuicidal ingestion of caustic sodium hydroxide solution (NaOH) often used in the local production of soaps. Various treatment modalities have been advocated for the treatment of esophageal stricture. In this study, we review the results of our adopted technique in the past 10 years for pedicled colonic interposition.

METHODS

This is a retrospective study of 21 patients who underwent substernal isoperistaltic pedicled colonic interposition graft for management of corrosive esophageal stricture. The right colon was pulled up into the neck in all the patients without resecting the strictured esophagus.

RESULTS

Long segment strictures and multiple strictures were the main indications for the procedure. The mean duration of the procedure was 339.6 ± 71.1 min. The average intraoperative blood loss was 673.1 ± 398.1 mL. There were two (9.5 %) hospital mortalities. Graft infarction (9.5 %), cervical fistulae (19.0 %), and reflux neo-esophagitis (14.3 %) were the main non-fatal complications. In the mid-term, dysphagia was completely relieved in a little over 84 % (16/19) of patients, while one patient (4.8 %) still experienced reflux neo-esophagitis requiring treatment. There was no case of gross regurgitation or nocturnal aspiration in the mid-term.

CONCLUSIONS

Although the use of pedicled colonic interposition graft offers a good mid-term functional outcome with relief of dysphagia, early postoperative morbidity is high. Graft infarction is the single most important factor for poor functional outcome and every effort must be made to prevent its occurrence.

摘要

背景

腐蚀性食管狭窄是尼日利亚人发病的主要原因。在大多数情况下,这是由于意外或自杀未遂摄入常用于当地肥皂生产的苛性氢氧化钠溶液(NaOH)所致。对于食管狭窄的治疗,人们提倡了各种治疗方式。在本研究中,我们回顾了过去10年中我们采用的带蒂结肠间置术的结果。

方法

这是一项对21例因腐蚀性食管狭窄接受胸骨后顺蠕动带蒂结肠间置移植术患者的回顾性研究。所有患者均将右结肠上提至颈部,未切除狭窄的食管。

结果

长段狭窄和多发狭窄是该手术的主要适应证。手术平均时长为339.6±71.1分钟。术中平均失血量为673.1±398.1毫升。有2例(9.5%)医院死亡病例。移植梗死(9.5%)、颈部瘘管(19.0%)和反流性新食管炎(14.3%)是主要的非致命并发症。在中期,略超过84%(16/19)的患者吞咽困难完全缓解,而1例患者(4.8%)仍有反流性新食管炎需要治疗。中期没有明显反流或夜间误吸的病例。

结论

尽管使用带蒂结肠间置移植术可在中期获得良好的功能结果,缓解吞咽困难,但术后早期发病率较高。移植梗死是导致功能结果不佳的最重要单一因素,必须尽一切努力预防其发生。

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