美国 2003-2006 年国家健康和营养调查中疫苗前时代人乳头瘤病毒 6、11、16 和 18 型血清阳性率。
Prevaccine era human papillomavirus types 6, 11, 16 and 18 seropositivity in the U.S.A., National Health and Nutrition Examination Surveys, 2003-2006.
机构信息
Division of Sexually Transmitted Disease Prevention, National Center for HIV/AIDS, Viral Hepatitis, Sexually Transmitted Disease, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
Sex Transm Infect. 2014 Sep;90(6):505-8. doi: 10.1136/sextrans-2013-051490. Epub 2014 Apr 19.
BACKGROUND
A vaccine is available to prevent human papillomavirus (HPV) 6, 11, 16 and 18; in the prevaccine era, seropositivity to vaccine types is a measure of natural exposure.
METHODS
We describe HPV seropositivity in the USA among 14-59-year-olds using the 2003-2006 National Health and Nutrition Examination Surveys.
RESULTS
Seropositivity to HPV 6, 11, 16 and 18 was 17.5%, 6.8%, 15.1% and 5.9%, respectively, among women, and 7.0%, 2.4%, 5.2% and 1.5%, respectively, among men. Overall in both sexes, seropositivity was 22.5% for any vaccine type (31.8% in women and 12.9% in men), but substantially lower for three or more types (1.7% overall, 2.8% in women and 0.6% in men).
CONCLUSIONS
Almost a quarter of the participants were seropositive to any HPV vaccine type but few were seropositive to at least three vaccine HPV types in the prevaccine era. Further study is needed to assess if seropositivity would be useful as a biological marker of vaccination.
背景
目前已有预防人乳头瘤病毒（HPV）6、11、16 和 18 的疫苗；在疫苗问世前，针对疫苗型别的血清阳性率是衡量自然感染的指标。
方法
我们利用 2003-2006 年全国健康和营养调查的数据，描述了美国 14-59 岁人群中针对 HPV 的血清阳性率。
结果
在女性中，HPV 6、11、16 和 18 的血清阳性率分别为 17.5%、6.8%、15.1%和 5.9%，在男性中分别为 7.0%、2.4%、5.2%和 1.5%。总体而言，两种性别中，任何一种疫苗型别的血清阳性率均为 22.5%（女性为 31.8%，男性为 12.9%），但三种或更多种型别的血清阳性率明显较低（总体为 1.7%，女性为 2.8%，男性为 0.6%）。
结论
将近四分之一的参与者针对任何一种 HPV 疫苗型别呈血清阳性，但在疫苗问世前，很少有人针对至少三种 HPV 疫苗型别呈血清阳性。需要进一步研究来评估血清阳性率是否可作为接种疫苗的生物学标志物。
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