用于治疗动脉粥样硬化性心血管疾病的免疫调节疗法的进展。
Advances in immune-modulating therapies to treat atherosclerotic cardiovascular diseases.
作者信息
Chyu Kuang-Yuh, Shah Prediman K
机构信息
Oppenheimer Atherosclerosis Research Center, Division of Cardiology, Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Division of Cardiology, Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 127 South San Vicente Boulevard, Suite A-3307, Los Angeles, CA 90048, USA.
出版信息
Ther Adv Vaccines. 2014 Mar;2(2):56-66. doi: 10.1177/2051013613514327.
In addition to hypercholesterolemia, innate and adaptive immune mechanisms play a critical role in atherogenesis, thus making immune-modulation therapy a potentially attractive way of managing atherosclerotic cardiovascular disease. These immune-modulation strategies include both active and passive immunization and confer beneficial reduction in atherosclerosis. Preclinical studies have demonstrated promising results and we review current knowledge on the complex role of the immune system and the potential for immunization as an immune-modulation therapy for atherosclerosis.
除了高胆固醇血症外，先天性和适应性免疫机制在动脉粥样硬化形成过程中起关键作用，因此免疫调节疗法成为治疗动脉粥样硬化性心血管疾病的一种潜在有吸引力的方法。这些免疫调节策略包括主动免疫和被动免疫，并能使动脉粥样硬化得到有益的减轻。临床前研究已取得了有前景的结果，我们综述了关于免疫系统复杂作用以及免疫接种作为动脉粥样硬化免疫调节疗法潜力的现有知识。
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