Panebianco Valeria, Barchetti Flavio, Musio Daniela, De Felice Francesca, Proietti Camilla, Indino Elena Lucia, Megna Valentina, Schillaci Orazio, Catalano Carlo, Tombolini Vincenzo
Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, 00161 Rome, Italy.
Department of Diagnostic and Molecular Imaging, Interventional Radiology, Nuclear Medicine and Radiation Therapy, University Hospital "Tor Vergata", 00133 Rome, Italy.
Biomed Res Int. 2014;2014:827265. doi: 10.1155/2014/827265. Epub 2014 Mar 13.
Currently the diagnosis of local recurrence of prostate cancer (PCa) after radical prostatectomy (RT) is based on the onset of biochemical failure which is defined by two consecutive values of prostate-specific antigen (PSA) higher than 0.2 ng/mL. The aim of this paper was to review the current roles of advanced imaging in the detection of locoregional recurrence. A nonsystematic literature search using the Medline and Cochrane Library databases was performed up to November 2013. Bibliographies of retrieved and review articles were also examined. Only those articles reporting complete data with clinical relevance for the present review were selected. This review article is divided into two major parts: the first one considers the role of PET/CT in the restaging of PCa after RP; the second part is intended to provide the impact of multiparametric-MRI (mp-MRI) in the depiction of locoregional recurrence. Published data indicate an emerging role for mp-MRI in the depiction of locoregional recurrence, while the performance of PET/CT still remains unclear. Moreover Mp-MRI, thanks to functional techniques, allows to distinguish between residual glandular healthy tissue, scar/fibrotic tissue, granulation tissue, and tumour recurrence and it may also be able to assess the aggressiveness of nodule recurrence.
目前，前列腺癌根治术后局部复发的诊断基于生化失败的出现，生化失败由连续两次前列腺特异性抗原（PSA）值高于0.2 ng/mL定义。本文的目的是综述先进成像技术在检测局部区域复发中的当前作用。截至2013年11月，使用Medline和Cochrane图书馆数据库进行了非系统性文献检索。还查阅了检索到的文章和综述文章的参考文献。仅选择那些报告了对本综述具有临床相关性的完整数据的文章。这篇综述文章分为两个主要部分：第一部分探讨PET/CT在前列腺癌根治术后再分期中的作用；第二部分旨在阐述多参数MRI（mp-MRI）在描绘局部区域复发方面的影响。已发表的数据表明，mp-MRI在描绘局部区域复发方面正发挥着越来越重要的作用，而PET/CT的表现仍不明确。此外，由于具备功能技术，mp-MRI能够区分残留的健康腺组织、瘢痕/纤维化组织、肉芽组织和肿瘤复发，并且还可能能够评估结节复发的侵袭性。
