McLaughlin Laura, Mahon Suzanne
School of Nursing, Saint Louis University in Missouri.
Oncol Nurs Forum. 2014 May;41(3):E194-202. doi: 10.1188/14.ONF.E194-E202.
To understand how taste impairment caused by head and neck cancer treatment changes over time or varies with treatment site or type.
Ovid MEDLINE® database was searched for reports of health-related quality of life (HRQOL) in head and neck cancer treatment survivors (HNCTS), which included taste function in a HRQOL instrument from 1946-2013. Eligible studies compared taste scores from baseline to post-treatment, using two treatment types or two cancer sites.
247 reports were identified; 19 were suitable for meta-analysis.
A series of dichotomous meta-analyses were conducted using comprehensive meta-analysis software .PRESENTATION OF FINDINGS: Taste scores were statistically significantly worse after treatment; the summary effect for the standard measure difference between pretreatment and post-treatment taste scores was 0.353 (p < 0.001). Patients treated with radiation therapy (RT) reported statistically significant worse taste function post-treatment than those who received no RT; the summary effect for the standard mean differences in taste scores was 0.77 (p = 0.001). Differences in tumor site were not significant.
Taste dysfunction is a long-term complication for HNCTS, and nurses should screen survivors for this sensory dysfunction.
了解头颈癌治疗引起的味觉障碍如何随时间变化，或因治疗部位或类型而异。
在Ovid MEDLINE®数据库中检索了头颈癌治疗幸存者（HNCTS）健康相关生活质量（HRQOL）的报告，其中包括1946 - 2013年HRQOL工具中的味觉功能。符合条件的研究比较了从基线到治疗后的味觉评分，采用两种治疗类型或两个癌症部位。
识别出247份报告；19份适合进行荟萃分析。
使用综合荟萃分析软件进行了一系列二分法荟萃分析。
治疗后味觉评分在统计学上显著更差；治疗前和治疗后味觉评分之间标准测量差异的汇总效应为0.353（p < 0.001）。接受放射治疗（RT）的患者治疗后报告的味觉功能在统计学上比未接受RT的患者更差；味觉评分标准均值差异的汇总效应为0.77（p = 0.001）。肿瘤部位的差异不显著。
味觉功能障碍是头颈癌治疗幸存者的长期并发症，护士应筛查幸存者的这种感觉功能障碍。
