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[透析及实验室检测方法在磷酸盐控制中的作用]

[The contribution of dialysis and laboratoristic methods for the control of phosphates].

作者信息

Bolasco Piergiorgio

出版信息

G Ital Nefrol. 2014 Mar-Apr;31(2).

Abstract

Prevention and correction of hyperphosphatemia is the first main goal of CKD-MBD management. Therefore, special attention is required to prevent a positive phosphate balance. In addition to a careful use of phosphate binders and dietary, phosphate control is needed to optimize the control of phosphate balance. In well-nourished patients is necessary to provide an optimal dialysis removal schedule. A solution could be the increase of the number of dialysis sessions per week and to carry out longer dialysis session strategies. Nevertheless, many patients have a high phosphate (P) intake linked to the high dietary protein requirement of dialysis patients, hence the use of intestinal P binders is mandatory to reduce P net intestinal absorption. Unfortunately the phosphate molecule must be considered as a medium molecular toxin. Nowadays it remains difficult to remove with modern dialysis strategies and ones clearance is still dependent on dialysis time. The best solutions are: hemodiafiltration with high-volume reinfusion, daily dialysis, long dialysis and modern peritoneal dialysis. Today, this scheduled strategies are difficult because of logistic and cost problems. However the milestone will be an adequate nutrition surveillance, especially with nursing collaboration toward dialysis treatments. This strategy should start in outpatient pre-dialysis ambulatory.

摘要

预防和纠正高磷血症是慢性肾脏病-矿物质和骨异常(CKD-MBD)管理的首要主要目标。因此,需要特别注意防止磷平衡为正。除了谨慎使用磷结合剂和控制饮食外,还需要控制磷以优化磷平衡的管理。对于营养良好的患者,有必要提供最佳的透析清除方案。一种解决方案可能是增加每周透析次数并采用延长透析时间的策略。然而,许多患者因透析患者对膳食蛋白质的高需求而摄入大量磷,因此必须使用肠道磷结合剂来减少肠道磷的净吸收。不幸的是,磷分子必须被视为一种中分子毒素。如今,采用现代透析策略仍难以清除,其清除率仍取决于透析时间。最佳解决方案是:高容量再输注血液透析滤过、每日透析、长时间透析和现代腹膜透析。如今,由于后勤和成本问题,这些既定策略实施起来很困难。然而,关键将是进行充分的营养监测,尤其是通过护理人员与透析治疗的协作。该策略应在门诊透析前门诊开始实施。

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