Department of Microbiology and Immunology; Hollings Cancer Center; Medical University of South Carolina; Charleston, SC USA.
Oncoimmunology. 2014 Jan 1;3(1):e27659. doi: 10.4161/onci.27659. Epub 2014 Jan 10.
It is unclear how tumor-associated macrophages (TAMs) contribute to the initiation of oncogenesis and how they are regulated at the molecular level. By using a lineage-specific deletion strategy, we found that heat shock protein 90kDa β (Grp94), member 1 (HSP90B1), a master chaperone for Toll-like receptors and integrins also known as GP96, critically endows TAMs with the ability to promote genotoxic stress and colitis-associated colon cancer.
目前尚不清楚肿瘤相关巨噬细胞（TAMs）如何促进肿瘤发生，以及它们在分子水平上是如何被调控的。通过使用谱系特异性缺失策略，我们发现热休克蛋白 90kDa β（Grp94）成员 1（HSP90B1），一种已知的 Toll 样受体和整合素的主要伴侣分子，也称为 GP96，赋予 TAMs 促进遗传毒性应激和结肠炎相关结肠癌的能力。
