Yau J C W, Kwong K P, Chung S W C, Ho Y Y, Xiao Y
a Centre for Food Safety, Food and Environmental Hygiene Department , Hong Kong Special Administrative Region , China.
Food Addit Contam Part B Surveill. 2008;1(2):93-9. doi: 10.1080/02652030802488142.
This paper reports levels of 3-monochloropropan-1,2-diol (3-MCPD) and 1,3-dichloro-2-propanol (1,3-DCP) in a wide range of food items and estimates their dietary exposure for secondary school students in Hong Kong. Dietary exposure to chloropropanols was estimated using local food consumption data obtained from secondary school students in 2000 and the concentrations of 3-MCPD and 1,3-DCP in food samples taken from the local market. The dietary exposure to 3-MCPD for an average secondary school student consumer was estimated to be 0.063-0.150 µg kg(-1) body weight (bw) day(-1), whilst that for the high consumer was 0.152-0.300 µg kg(-1) bw day(-1). Both estimates fell below the provisional maximum tolerable daily intake of 2 µg kg(-1) bw established by the Joint Expert Committee on Food Additives (JECFA) and amounted to less than 20% of this safety reference value. The dietary exposure to 1,3-DCP for an average secondary school student consumer was estimated to be 0.003-0.019 µg kg(-1) bw day(-1), whilst that for the high consumer was 0.009-0.040 µg kg(-1) bw day(-1). The resulting margins of exposures were of low concern for human health. It could be concluded that both the average and high secondary school student consumers were unlikely to experience major toxicological effects of 3-MCPD and 1,3-DCP.
本文报告了多种食品中3 - 一氯丙二醇(3 - MCPD)和1,3 - 二氯 - 2 - 丙醇(1,3 - DCP)的含量,并估算了香港中学生对它们的膳食摄入量。利用2000年从香港中学生那里获得的本地食物消费数据以及从本地市场采集的食品样本中3 - MCPD和1,3 - DCP的浓度,来估算膳食中氯丙醇的摄入量。据估算,一名普通中学生消费者对3 - MCPD的膳食摄入量为0.063 - 0.150微克/千克体重·天,而高摄入量消费者的摄入量为0.152 - 0.300微克/千克体重·天。这两个估算值均低于食品添加剂联合专家委员会(JECFA)确定的2微克/千克体重的暂定每日最大耐受摄入量,且不到该安全参考值的20%。据估算,一名普通中学生消费者对1,3 - DCP的膳食摄入量为0.003 - 0.019微克/千克体重·天,而高摄入量消费者的摄入量为0.009 - 0.040微克/千克体重·天。由此得出的暴露边际对人体健康的影响较低。可以得出结论,无论是普通中学生消费者还是高摄入量的中学生消费者,都不太可能受到3 - MCPD和1,3 - DCP的重大毒理学影响。