Hospital Santa Marta, Internal Medicine 4 , Lisbon , Portugal .
Clin Exp Hypertens. 2015;37(2):116-21. doi: 10.3109/10641963.2014.913605. Epub 2014 Apr 30.
This study aimed to assess the treatment patterns and prevalence of persistent lipid abnormalities in Portuguese hypertensive patients concomitantly treated with statins. Only 25% of the 656 hypertensive patients achieved the blood pressure goals in use during the study period. Similarly, only 33% and 37% attained the recommended levels of total cholesterol<4.5 mmol/L and LDL cholesterol<2.5 mmol/L, respectively. Relatively low doses of medium potency statins were the mainstay of therapy. There seems to be considerable room for improvement through the use of more potent statins, dose up-titration, and/or addition of other lipid-modifying therapies.
本研究旨在评估葡萄牙高血压患者同时接受他汀类药物治疗时的治疗模式和持续性脂质异常的流行情况。在研究期间,只有 656 名高血压患者中的 25%达到了血压目标。同样,只有 33%和 37%的患者分别达到了总胆固醇<4.5mmol/L 和 LDL 胆固醇<2.5mmol/L 的推荐水平。中效他汀类药物的相对低剂量是治疗的主要方法。通过使用更有效的他汀类药物、剂量滴定和/或添加其他脂质调节治疗,似乎有很大的改进空间。