了解肿瘤微环境对巨噬细胞对 CD40 激动剂反应的影响。
Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists.
机构信息
MedImmune Ltd.; Cambridge, UK.
出版信息
Oncoimmunology. 2014 Jan 1;3(1):e27615. doi: 10.4161/onci.27615. Epub 2014 Jan 6.
Abstract
Both T1 and T2 cytokines influence the antitumor functions of macrophages. We have recently shown that interferon γ (IFNγ) licenses the antineoplastic functions of CD40 ligand (CD40L)-stimulated macrophages more efficiently than interleukin (IL)-4 and IL-13. The presence of a T1 and T2 skewed tumor microenvironment may therefore influence therapeutic responses to CD40 agonists, agents that are showing promise in preliminary clinical trials.
摘要
T1 和 T2 细胞因子均影响巨噬细胞的抗肿瘤功能。我们最近发现，与白细胞介素（IL）-4 和 IL-13 相比，干扰素 γ（IFNγ）更有效地许可 CD40 配体（CD40L）刺激的巨噬细胞发挥抗肿瘤功能。因此，T1 和 T2 偏向性肿瘤微环境的存在可能会影响对 CD40 激动剂的治疗反应，这些激动剂在初步临床试验中显示出了前景。
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