Centers for Disease Control and Prevention, Epidemic Intelligence Service, Atlanta, GA ; Current affiliation: Kaiser Permanente Hawaii Medical Group, Honolulu, HI.
Hawaii Department of Health, Disease Outbreak Control Division, Honolulu, HI.
Public Health Rep. 2014 May;129(3):229-36. doi: 10.1177/003335491412900304.
We determined whether the administration time differed between seasonal intranasal live-attenuated influenza vaccine (LAIV) and seasonal injectable trivalent inactivated influenza vaccine (TIV) during Hawaii's 2009 school-located influenza vaccination clinics. This information is useful for public health response and allows further investigation into possible differences between the two vaccines.
We conducted a prospective cohort study in 15 public schools to determine mean times to administer LAIV and TIV to students. We performed group analyses to control for various clinic characteristics and conducted a stratified, weighted analysis.
A total of 4,701 students were enrolled in the study, and administration time was obtained for 3,869 (82%) students (1,492 [39%] LAIV and 2,377 [61%] TIV). The mean administration time for LAIV was 62 seconds and for TIV was 90 seconds, a difference of 28 seconds (p<0.01). This finding remained significant in the stratified analysis.
Although results indicated that both LAIV and TIV can be administered rapidly among school-aged populations, LAIV was faster to administer. This finding, in addition to the greater immunogenicity of LAIV compared with TIV among children, may be an important consideration for public health administrators in planning school-located mass vaccination clinics and encouraging patient acceptance of this vaccine.
我们确定了在夏威夷 2009 年学校定位流感疫苗接种诊所期间,季节性鼻内减毒活流感疫苗(LAIV)和季节性注射三价灭活流感疫苗(TIV)的给药时间是否存在差异。这些信息对于公共卫生应对很有用,并允许进一步调查两种疫苗之间可能存在的差异。
我们在 15 所公立学校进行了一项前瞻性队列研究,以确定向学生给予 LAIV 和 TIV 的平均时间。我们进行了组分析以控制各种诊所特征,并进行了分层加权分析。
共有 4701 名学生参加了这项研究,对 3869 名学生(1492 名[39%] LAIV 和 2377 名[61%] TIV)获得了给药时间。LAIV 的平均给药时间为 62 秒,TIV 为 90 秒,相差 28 秒(p<0.01)。分层分析中这一发现仍然具有统计学意义。
尽管结果表明 LAIV 和 TIV 都可以在学龄人群中快速给药,但 LAIV 的给药速度更快。除了 LAIV 比 TIV 在儿童中的免疫原性更强之外,这一发现可能是公共卫生管理人员在规划学校定位大规模疫苗接种诊所并鼓励患者接受这种疫苗时的一个重要考虑因素。