Firmann M, Medlin F, Hayoz D
Rev Med Suisse. 2014 Apr 9;10(425):782-7.
Cerebral small vessel disease (cSVD) represents the sum of lesions which define a rather new clinical entity. Indeed, lacunar infarcts which are acute events of cSVD, represent 25% of all ischemic strokes. However, only few studies have dealt with acute and long term management of such stroke. Despite its rather early description around the XIXth century, the "lacune", the cardinal anatomopathological lesion of cSVD, remains only partially explained and pathogenesis is still debated. The purpose of this paper is to better define the anatomical lesions, to discuss physiopathological hypotheses and to present the most salient clinical features. Once identified cSVD should not be further overlooked.
脑小血管病(cSVD)是一系列病变的统称,这些病变定义了一个相对较新的临床实体。事实上,腔隙性脑梗死作为cSVD的急性事件,占所有缺血性卒中的25%。然而,仅有少数研究涉及此类卒中的急性和长期管理。尽管在19世纪左右就有了对它的早期描述,但作为cSVD主要解剖病理病变的“腔隙”,其成因仍未完全明确,发病机制也仍存在争议。本文旨在更明确地界定解剖学病变,探讨病理生理假说,并呈现最显著的临床特征。一旦确诊,cSVD就不应再被忽视。