Mottolese M, Venturo I, Rinaldi M, Campioni N, Aluffi A, Curcio C G, Donnorso R P, Natali P G
Regina Elena Cancer Institute, Rome, Italy.
Cancer. 1989 Dec 15;64(12):2493-500. doi: 10.1002/1097-0142(19891215)64:12<2493::aid-cncr2820641215>3.0.co;2-s.
Transthoracic fine needle aspiration (FNA) biopsies performed under computed tomography (CT) scan (CT-FNA) have greatly improved the cytodiagnosis of lung tumors. However, the distinction between a primary lesion and a metastatic lesion still may be difficult on the basis of morphologic criteria. To evaluate whether a selected panel of monoclonal antibodies (MoAb) to tumor-associated antigens (TAA) can improve the diagnostic potential of FNA, we have immunocytochemically analyzed 122 pulmonary CT-FNA. Whereas conventional cytology was capable of recognizing only the neoplastic nature of the lesions, the immunocytochemical diagnosis could identify the primary or metastatic nature of the pulmonary masses in 92.5% of the cases. The immunocytochemical findings were confirmed by clinical-histopathologic data. The current results demonstrate that the use of immunocytochemical methods can significantly improve the diagnostic accuracy of conventional cytology of lung masses.
在计算机断层扫描（CT）引导下进行的经胸细针穿刺抽吸（FNA）活检（CT-FNA）极大地提高了肺肿瘤的细胞诊断水平。然而，根据形态学标准区分原发性病变和转移性病变仍可能存在困难。为了评估一组选定的针对肿瘤相关抗原（TAA）的单克隆抗体（MoAb）是否能提高FNA的诊断潜力，我们对122例肺部CT-FNA进行了免疫细胞化学分析。传统细胞学仅能识别病变的肿瘤性质，而免疫细胞化学诊断在92.5%的病例中能够确定肺部肿块的原发性或转移性性质。免疫细胞化学结果得到了临床病理数据的证实。目前的结果表明，使用免疫细胞化学方法可显著提高肺部肿块传统细胞学的诊断准确性。
