Yu Zhenzhong, Cai Menghao, Hu Wei, Zhang Ying, Zhou Jiao, Zhou Xiangshan, Zhang Yuanxing
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Res Microbiol. 2014 Jul-Aug;165(6):462-7. doi: 10.1016/j.resmic.2014.04.003. Epub 2014 May 2.
A cyclin-like protein from Aspergillus nidulans, ClgA, was identified. Its cyclin-like subunit shares 28.3% identity to Saccharomyces cerevisiae Clg1. Deletion of clgA slightly influenced fungal growth, but repressed asexual development and made it more sensitive to temperature variations. It also downregulated expression of brlA, abaA and wetA, which are critically responsible for asexual development. Sexual development was impaired in the ΔclgA mutant. Its related genes, veA and nosA, were expressed weakly in the ΔclgA mutant, while nsdD expression showed the opposite behavior. Generally, ClgA functioned differently from other reported cyclins in development of A. nidulans.
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