He Kuang, Bauer Carl E
Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA.
Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA.
Trends Microbiol. 2014 Jul;22(7):389-98. doi: 10.1016/j.tim.2014.04.004. Epub 2014 May 1.
Recent studies have revealed that several Gram-negative species utilize variations of the well-known chemotaxis signaling cascade to switch lifestyles in order to survive environmental stress. The two survival strategies covered in this review are the development of dormant cyst cells and biofilm formation. Each of these structures involves exopolysaccharide-mediated cell-cell interactions, which result in multicellular communities that confer resistance to stress conditions such as desiccation and antibiotics. This review is centered on recent advances in the understanding of phosphate flow and novel output signals in chemosensory signaling pathways that are involved in cyst formation and biofilms.
最近的研究表明，几种革兰氏阴性菌利用著名的趋化信号级联反应的变体来改变生活方式，以在环境压力下生存。本综述涵盖的两种生存策略是休眠囊胞细胞的形成和生物膜的形成。这些结构中的每一种都涉及胞外多糖介导的细胞间相互作用，从而形成多细胞群落，赋予对干燥和抗生素等应激条件的抗性。本综述聚焦于对参与囊胞形成和生物膜的化学感应信号通路中磷酸盐流动和新型输出信号的理解的最新进展。
