Li C G, Rand M J
Department of Pharmacology, University of Melbourne, Victoria, Australia.
Eur J Pharmacol. 1989 Sep 1;168(1):107-10. doi: 10.1016/0014-2999(89)90640-7.
The muscarinic agonist McN-A-343 did not affect the tone or nitroprusside-induced relaxations of the rat anococcygeus, but inhibited non-adrenergic non-cholinergic (NANC) relaxations. Atropine, pirenzepine and gallamine blocked the McN-A-343 inhibition of NANC relaxations. Agonists of alpha 1-(methoxamine) or alpha 2-adrenoceptors (clonidine, rilmenidine) increased tone and reduced NANC relaxations. Carbachol also increased tone but produced a greater reduction of NANC relaxations. The findings suggest that activation of prejunctional muscarinic receptors on NANC terminals inhibits transmitter release, but there is no evidence for prejunctional alpha-adrenoceptors.
毒蕈碱激动剂 McN - A - 343 不影响大鼠肛门尾骨肌的张力或硝普钠诱导的舒张，但可抑制非肾上腺素能非胆碱能（NANC）舒张。阿托品、哌仑西平和加拉明可阻断 McN - A - 343 对 NANC 舒张的抑制作用。α1 - 肾上腺素受体激动剂（甲氧明）或α2 - 肾上腺素受体激动剂（可乐定、利美尼定）可增加张力并减少 NANC 舒张。卡巴胆碱也可增加张力，但对 NANC 舒张的减少作用更大。这些发现表明，NANC 神经末梢上的节前毒蕈碱受体激活可抑制递质释放，但没有证据表明存在节前α - 肾上腺素受体。
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