Hashimoto Michio
Nihon Rinsho. 2014 Apr;72(4):648-56.
Docosahexaenoic acid, the most abundant omega3 fatty acid in the brain, plays a role in cognitive development, learning ability, neuronal membrane plasticity, synaptogenesis, and neurogenesis, all of which are involved in synaptic transmission and the well-being of normal brain functions, and search on the functionality is still in progress. Establishment of prevention and treatment of neuropsychiatric illnesses, such as dementia is not easy, but from numerous basic and epidemiological studies, increase of omega3 fatty acid dietary intake is reported likely to prevent the onset of dementia. This paper is outlined the relevance of cognitive function and omega3 fatty acids, especially docosahexaenoic acid, and the possibility of preventive effect of the fatty acid on dementia.
二十二碳六烯酸是大脑中含量最丰富的ω-3脂肪酸,在认知发展、学习能力、神经元膜可塑性、突触形成和神经发生中发挥作用,所有这些都参与突触传递和正常脑功能的健康,并且对其功能的研究仍在进行中。建立神经精神疾病如痴呆症的预防和治疗并不容易,但从大量基础研究和流行病学研究来看,据报道增加ω-3脂肪酸的饮食摄入量可能预防痴呆症的发生。本文概述了认知功能与ω-3脂肪酸尤其是二十二碳六烯酸的相关性,以及该脂肪酸对痴呆症的预防作用可能性。