Qingdao Center for Disease Control and Prevention, Qingdao, 266033, Shandong, People's Republic of China.
Arch Virol. 2014 Sep;159(9):2497-502. doi: 10.1007/s00705-014-2067-6. Epub 2014 May 6.
To characterize the genetic properties of coxsackievirus A12 (CVA12) strains isolated from hand, foot and mouth disease (HFMD) patients in Qingdao during 2008-2011, the complete genome and VP1 coding region were sequenced and analyzed. Phylogenetic analysis showed that all strains from China clustered into three different branches, suggesting multiple lineages of CVA12 co-circulating in Asia. Sequence analysis indicated a monophyletic group only when the P1 region was examined, indicating possible recombination between CVA12 and other HEV-A serotypes. The emergence of CVA12 involved in an HFMD outbreak in China is a public-health issue.
为了研究 2008-2011 年青岛手足口病患者中分离出的柯萨奇病毒 A12（CVA12）株的遗传特性，对其全基因组和 VP1 编码区进行了测序和分析。系统进化分析表明，中国的所有毒株均聚为 3 个不同的分支，提示亚洲存在多种 CVA12 循环株。只有当 P1 区被检测到时，序列分析才显示出单系群，提示 CVA12 与其他肠道病毒 A 血清型之间可能存在重组。在中国手足口病疫情中出现的 CVA12 是一个公共卫生问题。
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