Huang Fengming, Guo Jing, Zou Zhen, Liu Jun, Cao Bin, Zhang Shuyang, Li Hui, Wang Wei, Sheng Miaomiao, Liu Song, Pan Jingcao, Bao Changjun, Zeng Mei, Xiao Haixia, Qian Guirong, Hu Xinjun, Chen Yuanting, Chen Yu, Zhao Yan, Liu Qiang, Zhou Huandi, Zhu Jindong, Gao Hainv, Yang Shigui, Liu Xiaoli, Zheng Shufa, Yang Jiezuan, Diao Hongyan, Cao Hongcui, Wu Ying, Zhao Min, Tan Shuguang, Guo Dan, Zhao Xiliang, Ye Yicong, Wu Wei, Xu Yingchun, Penninger Josef M, Li Dangsheng, Gao George F, Jiang Chengyu, Li Lanjuan
1] State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry, Peking Union Medical College, Tsinghua University, Beijing 100005, China [2].
1] State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China [2] Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China [3].
Nat Commun. 2014 May 6;5:3595. doi: 10.1038/ncomms4595.
A novel influenza A (H7N9) virus of avian origin emerged in eastern China in the spring of 2013. This virus causes severe disease in humans, including acute and often lethal respiratory failure. As of January 2014, 275 cases of H7N9-infected patients had been reported, highlighting the urgency of identifying biomarkers for predicting disease severity and fatal outcomes. Here, we show that plasma levels of angiotensin II, a major regulatory peptide of the renin-angiotensin system, are markedly elevated in H7N9 patients and are associated with disease progression. Moreover, the sustained high levels of angiotensin II in these patients are strongly correlated with mortality. The predictive value of angiotensin II is higher than that of C-reactive protein and some clinical parameters such as the PaO2/FiO2 ratio (partial pressure of arterial oxygen to the fraction of inspired oxygen). Our findings indicate that angiotensin II is a biomarker for lethality in flu infections.
一种源自禽类的新型甲型H7N9流感病毒于2013年春季在中国东部出现。这种病毒可导致人类严重疾病，包括急性且往往致命的呼吸衰竭。截至2014年1月，已报告275例H7N9感染患者，这凸显了识别预测疾病严重程度和致命结局生物标志物的紧迫性。在此，我们表明，肾素-血管紧张素系统的主要调节肽血管紧张素II的血浆水平在H7N9患者中显著升高，并与疾病进展相关。此外，这些患者中血管紧张素II的持续高水平与死亡率密切相关。血管紧张素II的预测价值高于C反应蛋白以及一些临床参数，如PaO2/FiO2比值（动脉血氧分压与吸入氧分数之比）。我们的研究结果表明，血管紧张素II是流感感染致死率的一种生物标志物。
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