[口蹄疫病毒的抗原结构。III. 口蹄疫病毒O1K和A22株VP1蛋白免疫显性区序列合成肽的免疫原性]

[Antigenic structure of the foot-and-mouth disease virus. III. Immunogenic properties of synthetic peptides of the sequence of the immunodominant region of VP1 proteins of the O1K and A22 strains of foot-and-mouth virus].

作者信息

Surovoĭ A Iu, Gel'fanov V M, Vol'pina O M, Ivanov V T, Chepurkin A V, Chepurkin A V, Ivaniushchenkov V M, Driagalin N N, Burdov A N

出版信息

Bioorg Khim. 1989 Sep;15(9):1185-92.

Abstract

Immunogenic and protective properties of uncoupled and KLH-conjugated peptides covering the sequence of the immunodominant region of VP1 proteins of the O1K and A22 strains of foot-and-mouth disease virus have been studied. The uncoupled peptides 136-148 O1K, 136-152 O1K, 131-149 A22 and 140-149 A22 were shown to be immunogenic in guinea pigs and induced 50-100% protection against homologous virus. On the other hand, the A22 specific peptides, in contrast to the O1K peptides, were not immunogenic in rabbits. Immunization of nonresponders with the A22 specific peptides containing the O1K peptide can bypass nonresponsiveness to the A22 peptide in terms of the antibody production. The induced antibodies showed virus-neutralizing activity in vitro.

摘要

对口蹄疫病毒O1K和A22株VP1蛋白免疫显性区序列的非偶联肽和钥孔血蓝蛋白（KLH）偶联肽的免疫原性和保护特性进行了研究。已证明非偶联肽136 - 148 O1K、136 - 152 O1K、131 - 149 A22和140 - 149 A22在豚鼠中具有免疫原性，并诱导了50 - 100%的同源病毒保护作用。另一方面，与O1K肽相比，A22特异性肽在兔中没有免疫原性。用含有O1K肽的A22特异性肽对无反应者进行免疫，可以在抗体产生方面绕过对A22肽的无反应性。诱导产生的抗体在体外显示出病毒中和活性。

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