Kilimcioglu Ali Ahmet, Havlucu Yavuz, Girginkardesler Nogay, Celik Pınar, Yereli Kor, Özbilgin Ahmet
Department of Parasitology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey.
Department of Chest Disease, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey.
Biomed Res Int. 2014;2014:912346. doi: 10.1155/2014/912346. Epub 2014 Apr 3.
Flagellated protozoa that cause bronchopulmonary symptoms in humans are commonly neglected. These protozoal forms which were presumed to be "flagellated protozoa" have been previously identified in immunosuppressed patients in a number of studies, but have not been certainly classified so far. Since no human cases of bronchopulmonary flagellated protozoa were reported from Turkey, we aimed to investigate these putative protozoa in immunosuppressed patients who are particularly at risk of infectious diseases. Bronchoalveolar lavage fluid samples of 110 immunosuppressed adult patients who were admitted to the Department of Chest Diseases, Hafsa Sultan Hospital of Celal Bayar University, Manisa, Turkey, were examined in terms of parasites by light microscopy. Flagellated protozoal forms were detected in nine (8.2%) of 110 cases. Metronidazole (500 mg b.i.d. for 30 days) was given to all positive cases and a second bronchoscopy was performed at the end of the treatment, which revealed no parasites. In conclusion, immunosuppressed patients with bronchopulmonary symptoms should attentively be examined with regard to flagellated protozoa which can easily be misidentified as epithelial cells.
引起人类支气管肺部症状的鞭毛虫原生动物通常被忽视。这些被认为是“鞭毛虫原生动物”的原生动物形态此前在多项研究中已在免疫抑制患者中被发现，但迄今为止尚未得到明确分类。由于土耳其尚未报告人类支气管肺部鞭毛虫病例，我们旨在对特别易患传染病的免疫抑制患者中的这些假定原生动物进行调查。对土耳其马尼萨市切拉尔·贝亚尔大学哈夫萨·苏丹医院胸科收治的110例免疫抑制成年患者的支气管肺泡灌洗液体样本进行了寄生虫光学显微镜检查。在110例病例中有9例（8.2%）检测到鞭毛虫原生动物形态。对所有阳性病例给予甲硝唑（500毫克，每日两次，共30天），治疗结束时进行了第二次支气管镜检查，结果未发现寄生虫。总之，对于有支气管肺部症状的免疫抑制患者，应仔细检查是否存在易被误认作上皮细胞的鞭毛虫原生动物。
