依诺昔酮对慢性心力衰竭的急性作用。

Acute effects of enoximone in chronic heart failure.

作者信息

Saborowski F, Peters P, Schneider M, Fehske W, Dieterich H A

机构信息

Department of Internal Medicine, Hospital Holweide, Cologne, F.R.G.

出版信息

J Cardiovasc Pharmacol. 1989;14 Suppl 1:S57-61.

PMID:2480487

Abstract

In 19 patients with chronic heart failure in NYHA stages III and IV, hemodynamic measurements were made using a Swan-Ganz catheter before and 15 and 30 min after intravenous administration of enoximone. Group A (n = 10) received 1.0 mg of enoximone/kg of body weight and group B (n = 9) received 1.5 mg of enoximone/kg of body weight. In group A, there was a rise in the pulse rate of 13% and in the cardiac index of 13% with unchanged stroke volume index. At constant mean arterial pressure, the mean right atrial pressure fell by 28%, the mean pulmonary arterial pressure by 11%, the total peripheral resistance by 13%, and the total pulmonary resistance by 21% after 30 min. In group B, the pulse rate rose by 9.8%, the mean blood pressure by 2.7%, the cardiac index by 31.4%, and the stroke volume index by 18.4% 30 min after administration of enoximone, whereas a fall in the mean right atrial pressure by 57.4%, the mean pulmonary arterial pressure by 28.6%, the total peripheral resistance by 26.0%, and the total pulmonary resistance by 45.3% could be shown. At a low dosage of enoximone, the vasodilatory effects of this substance are most prominent, whereas an increase in the pumping performance of the heart could be clearly demonstrated in higher dose ranges.

摘要

对19例纽约心脏协会（NYHA）心功能Ⅲ级和Ⅳ级的慢性心力衰竭患者，在静脉注射依诺昔酮前以及注射后15分钟和30分钟，使用Swan - Ganz导管进行血流动力学测量。A组（n = 10）接受1.0毫克依诺昔酮/千克体重，B组（n = 9）接受1.5毫克依诺昔酮/千克体重。在A组中，心率上升了13%，心脏指数上升了13%，每搏量指数不变。在平均动脉压恒定的情况下，30分钟后平均右心房压下降了28%，平均肺动脉压下降了11%，总外周阻力下降了13%，总肺阻力下降了21%。在B组中，注射依诺昔酮30分钟后，心率上升了9.8%，平均血压上升了2.7%，心脏指数上升了31.4%，每搏量指数上升了18.4%，而平均右心房压下降了57.4%，平均肺动脉压下降了28.6%，总外周阻力下降了26.0%，总肺阻力下降了45.3%。在依诺昔酮低剂量时，该物质的血管舒张作用最为显著，而在较高剂量范围内可明显显示心脏泵血功能增强。