Lee Suh-Young, Lim Kyoung-Whan, Chang Yoon-Seok
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744, Korea. ; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 110-744, Korea. ; Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 463-707, Korea.
Asia Pac Allergy. 2014 Apr;4(2):119-25. doi: 10.5415/apallergy.2014.4.2.119. Epub 2014 Apr 29.
Radiocontrast media (RCM) is a major cause of drug hypersensitivity reactions as the medical application of RCM is increasing recently. RCM induced hypersensitivity reactions are considered as unpredictable type B reactions. Underlying mechanism of RCM induced hypersensitivity was previously regarded as nonimmunological mechanisms but recent studies suggest that immunological mechanisms could also be involved. As a result, the roles of skin tests and premedication are revisiting. As there has been no report that comprehensively summarized and analyzed the results of the studies on RCM hypersensitivity in the Asia Pacific region, we aimed to review the literatures on hypersensitivity reactions to RCM in terms of prevalence clinical manifestations, diagnostic approach, and preventive measures in the Asia Pacific region.
随着近年来放射造影剂（RCM）在医学上的应用不断增加，它已成为药物过敏反应的主要原因。RCM诱导的过敏反应被认为是不可预测的B型反应。RCM诱导的过敏反应的潜在机制以前被认为是非免疫机制，但最近的研究表明免疫机制也可能参与其中。因此，皮肤试验和预防用药的作用正在重新受到审视。由于尚无全面总结和分析亚太地区RCM过敏反应研究结果的报告，我们旨在从亚太地区RCM过敏反应的患病率、临床表现、诊断方法和预防措施等方面对相关文献进行综述。
