单个噻唑橙分子在DNA i-基序中形成激基复合物。
A single thiazole orange molecule forms an exciplex in a DNA i-motif.
作者信息
Xu Baochang, Wu Xiangyang, Yeow Edwin K L, Shao Fangwei
机构信息
Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
出版信息
Chem Commun (Camb). 2014 Jun 18;50(48):6402-5. doi: 10.1039/c4cc01147c.
PMID:24811922
Abstract
A fluorescent exciplex of thiazole orange (TO) is formed in a single-dye conjugated DNA i-motif. The exciplex fluorescence exhibits a large Stokes shift, high quantum yield, robust response to pH oscillation and little structural disturbance to the DNA quadruplex, which can be used to monitor the folding of high-order DNA structures.
摘要
在单染料共轭的DNA i-基序中形成了噻唑橙（TO）的荧光激基复合物。该激基复合物荧光具有大斯托克斯位移、高量子产率、对pH振荡的稳健响应以及对DNA四链体的结构干扰小等特点，可用于监测高阶DNA结构的折叠。
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