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肺癌肿瘤组织中镉含量而非砷含量与吸烟、组织病理学类型及分期的关联。

Association of cadmium but not arsenic levels in lung cancer tumor tissue with smoking, histopathological type and stage.

作者信息

Demir Nalan, Enon Serkan, Turksoy Vugar Ali, Kayaalti Zeliha, Kaya Seda, Cangir Ayten Kayi, Soylemezoglu Tulin, Savas Ismail

机构信息

Department of Chest Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey E-mail :

出版信息

Asian Pac J Cancer Prev. 2014;15(7):2965-70. doi: 10.7314/apjcp.2014.15.7.2965.

DOI:10.7314/apjcp.2014.15.7.2965

PMID:24815432

Abstract

BACKGROUND

To evaluate association of lung cancer with arsenic and cadmium levels measured in tumor tissue.

MATERIALS AND METHODS

Ninety-five patients with lung cancer tumor tissue obtained surgically were included in this study. Arsenic and cadmium levels were measured and levels of metals were compared among types of lung cancer and with reference to patient data.

RESULTS

The histopathologic diagnoses of the 95 cases were SCC, 49, adenocarcinoma, 28, large cell, 11 and SCLC, 1. Mean tumor arsenic and cadmium levels were 149.3±129.1μg/kg and 276.3±219.3μg/kg, respectively. Cadmium levels were significantly associated with smoking (p=0.02), histopathologic type (p=0.005), and TNM staging (r=0.325; p=0.001), although arsenic was not related to any parameter (p>0.05). There was no relation between metal levels and mortality (p>0.05).

CONCLUSIONS

We found a significant association between tumor cadmium levels of patients with lung cancer and smoking, histopathologic type and staging, although there was no relation with arsenic levels.

摘要

背景

评估肺癌与肿瘤组织中测得的砷和镉水平之间的关联。

材料与方法

本研究纳入了95例通过手术获取肺癌肿瘤组织的患者。测量了砷和镉水平，并在肺癌类型之间以及参照患者数据比较了金属水平。

结果

95例患者的组织病理学诊断为鳞状细胞癌（SCC）49例、腺癌28例、大细胞癌11例和小细胞肺癌（SCLC）1例。肿瘤砷和镉的平均水平分别为149.3±129.1μg/kg和276.3±219.3μg/kg。镉水平与吸烟（p=0.02）、组织病理学类型（p=0.005）和TNM分期（r=0.325；p=0.001）显著相关，而砷与任何参数均无关联（p>0.05）。金属水平与死亡率之间无关联（p>0.05）。