Ryberg M, Johansson I, Ericson T, Mörnstad H, Henriksson R, Jönsson G, Sundström S
Department of Cariology, University of Umeå, Sweden.
J Oral Pathol Med. 1989 Oct;18(9):529-32. doi: 10.1111/j.1600-0714.1989.tb01357.x.
The effects of long-term beta-adrenoceptor stimulation or inhibition on parotid and submandibular glands, saliva secretion, and caries development were studied. Groups of rats were treated daily with: 0.5 or 5 mg/kg body weight of isoproterenol (IPR), 0.5 or 5 mg/kg bw propranolol (PRO), or saline. After 42 days, saliva was collected and analyzed for secretion rate, total protein, amylase, sialic acid and electrolytes. Total protein and amylase in saliva decreased and potassium increased in the high IPR group. Phosphate increased in both IPR groups and decreased in the high PRO group. The average weight of parotid glands increased 3.7 times in the high IPR group and 1.8 times in the low IPR group. Amylase and total protein in parotid gland extracts decreased in both IPR groups. The submandibular gland weight increased 1.5 times in the high IPR group. Total protein decreased in the high IPR group. There was no difference in caries development.
研究了长期β-肾上腺素能受体刺激或抑制对腮腺和颌下腺、唾液分泌及龋齿发展的影响。将大鼠分组,每天给予:0.5或5mg/kg体重的异丙肾上腺素(IPR)、0.5或5mg/kg体重的普萘洛尔(PRO),或生理盐水。42天后,收集唾液并分析其分泌率、总蛋白、淀粉酶、唾液酸和电解质。高剂量IPR组唾液中的总蛋白和淀粉酶减少,钾增加。两个IPR组的磷酸盐均增加,高剂量PRO组的磷酸盐减少。高剂量IPR组腮腺平均重量增加3.7倍,低剂量IPR组增加1.8倍。两个IPR组腮腺提取物中的淀粉酶和总蛋白均减少。高剂量IPR组颌下腺重量增加1.5倍。高剂量IPR组总蛋白减少。龋齿发展方面无差异。