黄连的降血糖作用及其作用机制：系统评价与药理学研究综述
The antihyperglycemic effects of Rhizoma Coptidis and mechanism of actions: a review of systematic reviews and pharmacological research.
作者信息
Wang Hui, Mu Wei, Shang Hongcai, Lin Jia, Lei Xiang
机构信息
Tianjin Institute for Clinical Evaluation of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 88 Yuquan Road, Nankai District, Tianjin 300193, China.
出版信息
Biomed Res Int. 2014;2014:798093. doi: 10.1155/2014/798093. Epub 2014 Apr 10.
Abstract
Rhizoma Coptidis (Huang Lian in Chinese pinyin) is among the most widely used traditional Chinese herbal medicines and has a profound history of more than 2000 years of being used as a therapeutic herb. The antidiabetic effects of Rhizoma Coptidis have been extensively investigated in animal experiments and clinical trials and its efficacy as a promising antihyperglycemic agent has been widely discussed. In the meantime, findings from modern pharmacological studies have contributed the majority of its bioactivities to berberine, the isoquinoline alkaloids component of the herb, and a number of experiments testing the antidiabetic effects of berberine have been initiated. Therefore, we conducted a review of the current evidence profile of the antihyperglycemic effects of Rhizoma Coptidis as well as its main component berberine and the possible mechanism of actions, in order to summarize research evidence in this area and identify future research directions.
摘要
黄连是使用最为广泛的传统中草药之一，作为治疗草药已有2000多年的悠久历史。黄连的抗糖尿病作用已在动物实验和临床试验中得到广泛研究，其作为一种有前景的降血糖药物的功效也得到了广泛讨论。与此同时，现代药理学研究结果表明，该草药的大多数生物活性都归因于其异喹啉生物碱成分小檗碱，并且已经开展了一些测试小檗碱抗糖尿病作用的实验。因此，我们对黄连及其主要成分小檗碱的降血糖作用的现有证据概况以及可能的作用机制进行了综述，以便总结该领域的研究证据并确定未来的研究方向。
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