Hashemi Sadraddin Rasi, Noshad Hamid, Yazdaninia Iman, Sohrabi Bahram, Separham Ahmad
Cardiovascular Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
Saudi J Kidney Dis Transpl. 2014 May;25(3):524-9. doi: 10.4103/1319-2442.132159.
To evaluate QT dispersion (QTd) in dialysis patients in an analytic cross-sectional study, three groups were enrolled: Hemodialysis (HD), peritoneal dialysis (PD) and control (30 patients in each group) to study QT parameters in 12-lead electrocardiograms (ECGs). QTd was calculated (maximum QT interval minus minimum QT interval in different leads in each ECG). In dialysis patients, left ventricle mass index (LVMI) was also evaluated using the ECG of the patients. QT, corrected QT (QTc), QTd and QTc dispersion were significantly higher in the HD and PD groups than in controls, but there was no difference between the dialysis groups. There was no difference between the HD and the PD groups in LVMI and ejection fraction. In the PD group, there was a positive correlation of LVMI and QTd (r = 0.5, P = 0.004) and QTc dispersion (r = 0.54, P = 0.004). We conclude that the QT changes were more prominent in HD and PD patients than in controls, which could be due to electrolyte changes. Further studies to evaluate the causes of the QT changes in a larger population are needed.
在一项分析性横断面研究中,为评估透析患者的QT离散度(QTd),招募了三组对象:血液透析(HD)组、腹膜透析(PD)组和对照组(每组30例患者),以研究12导联心电图(ECG)中的QT参数。计算QTd(每个ECG不同导联中最大QT间期减去最小QT间期)。在透析患者中,还利用患者的ECG评估左心室质量指数(LVMI)。HD组和PD组的QT、校正QT(QTc)、QTd和QTc离散度显著高于对照组,但透析组之间无差异。HD组和PD组在LVMI和射血分数方面无差异。在PD组中,LVMI与QTd(r = 0.5,P = 0.004)和QTc离散度(r = 0.54,P = 0.004)呈正相关。我们得出结论,HD和PD患者的QT变化比对照组更显著,这可能是由于电解质变化所致。需要进一步开展研究,以在更大规模人群中评估QT变化的原因。