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[使用苏联产巴曲酶替代品测定纤维蛋白原]

[The use of Soviet substitutes for batroxobin in the determination of fibrinogen].

作者信息

Iakunin G A, Smolianitskiĭ A Ia, Iukel'son L Ia, Barabanshchikova N A, Sadykov E S, Zolotukhin S V, Shumbalina L F, Lavrova L A

出版信息

Lab Delo. 1989(12):36-8.

PMID:2483200
Abstract

Plasma fibrinogen was measured by kinetic photometry with two Soviet analogs of the foreign agent batroxobin: ancistron-N and agichal, obtained from Central Asian Aspidelaps lubricus venom by different techniques. Both the preparations of thrombin-like enzyme from the venom have proved to be adequate substituents of batroxobin; the optimal concentration of ancistron-N for this test was found to be 20 micrograms/ml or 0.04 U/ml, that of agichal 0.5 micrograms/ml.

摘要

采用动力学光度法,用两种苏联产的国外药物巴曲酶类似物(分别是从中亚珊瑚蛇毒液中通过不同技术获得的安奇斯托酶 - N和阿吉哈尔)测定血浆纤维蛋白原。结果表明,这两种来自蛇毒的类凝血酶制剂都是巴曲酶的合适替代品;该试验中安奇斯托酶 - N的最佳浓度为20微克/毫升或0.04单位/毫升,阿吉哈尔的最佳浓度为0.5微克/毫升。

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