1例类风湿关节炎与局限性系统性硬化症重叠综合征患者，使用托珠单抗成功治疗关节炎及伴发的全身淋巴结肿大和原发性胆汁性肝硬化。
A case of rheumatoid arthritis and limited systemic sclerosis overlap successfully treated with tocilizumab for arthritis and concomitant generalized lymphadenopathy and primary biliary cirrhosis.
作者信息
Saito Eiko, Sato Shinji, Nogi Shinichi, Sasaki Noriko, Chinen Naofumi, Honda Kiri, Wakabayashi Takayuki, Yamada Chiho, Nakamura Naoya, Suzuki Yasuo
机构信息
Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, 142 Shimokasuya, Isehara 160-8582, Japan.
Department of Pathology, Tokai University School of Medicine, 142 Shimokasuya, Isehara 160-8582, Japan.
出版信息
Case Rep Rheumatol. 2014;2014:386328. doi: 10.1155/2014/386328. Epub 2014 Apr 15.
Abstract
A 57-year-old woman with rheumatoid arthritis (RA) and limited systemic sclerosis (lSSc) was suspected to have lymphadenopathy and primary biliary cirrhosis (PBC). Lymph node biopsy showed reactive follicular lymphadenopathy with intrafollicular plasmacyte infiltration that was interleukin-6 positive by immunohistostaining. Because of gradually worsening arthritis, tocilizumab was administered and arthritis improved markedly. Interestingly, lymphadenopathy and PBC improved simultaneously. This suggested that interleukin-6 might play an important role in reactive lymphadenopathy and PBC associated with RA/lSSc.
摘要
一名患有类风湿关节炎（RA）和局限性系统性硬化症（lSSc）的57岁女性被怀疑有淋巴结病和原发性胆汁性肝硬化（PBC）。淋巴结活检显示反应性滤泡性淋巴结病，伴有滤泡内浆细胞浸润，免疫组化染色显示白细胞介素-6呈阳性。由于关节炎逐渐加重，给予托珠单抗治疗，关节炎明显改善。有趣的是，淋巴结病和PBC同时改善。这表明白细胞介素-6可能在与RA/lSSc相关的反应性淋巴结病和PBC中起重要作用。
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