Shin Sung, Han Duck Jong, Kim Young Hoon, Han Seungbong, Choi Byung Hyun, Jung Joo Hee, Cho Han Kyung
1 Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 2 Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, Seoul, Korea. 3 Address correspondence to: Duck Jong Han, M.D., Ph.D., Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, 388-1 Pungnap-2dong, Songpa-gu, Seoul 138-736, Korea.
Transplantation. 2014 Dec 27;98(12):1316-22. doi: 10.1097/TP.0000000000000214.
Compared with the impact of delayed graft function (DGF) after renal transplantation, DGF after pancreas transplantation has not been fully evaluated.
We retrospectively verified the impact of DGF on long-term pancreas graft survival in surgically successful cases. Pancreas graft failure was defined by the recipient's return to exogenous insulin administration.
Between May 2004 and April 2013, we performed 135 technically successful primary pancreas transplantations. Delayed graft function was defined as a total cumulative insulin requirement of 19 UI or greater within postoperative 7 days. Of the 135 recipients in our study cohort, 47 (34.8%) developed DGF after the pancreas transplantation. By multivariate analysis, DGF was found to be associated with a donor age of 30 years or older (odds ratio, 3.4; 95% confidence interval, 1.50-7.69; P=0.003) and the increased ratio of body mass index in a recipient to a donor (odds ratio, 26.1; 95% confidence interval, 2.53-270.0; P=0.006). There was a trend toward higher acute rejection (P=0.622) and mortality (P=0.49) rates in recipients with versus without DGF, although this did not reach statistical significance. Delayed graft function was found to be associated with a greater risk of overall pancreas graft failure (P=0.016) and death-censored graft failure (P=0.037).
Delayed graft function after pancreas transplantation was found to be associated with a greater risk of overall pancreas graft failure and death-censored graft failure.
与肾移植后延迟移植肾功能（DGF）的影响相比，胰腺移植后DGF尚未得到充分评估。
我们回顾性验证了DGF对手术成功病例中胰腺移植长期存活的影响。胰腺移植失败定义为受者恢复使用外源性胰岛素。
2004年5月至2013年4月期间，我们进行了135例技术成功的初次胰腺移植。延迟移植肾功能定义为术后7天内胰岛素总累积需求量达到19 UI或更高。在我们的研究队列中的135名受者中，47名（34.8%）在胰腺移植后发生了DGF。通过多变量分析，发现DGF与供体年龄30岁或以上（比值比，3.4；95%置信区间，1.50 - 7.69；P = 0.003）以及受者与供体体重指数增加比例相关（比值比，26.1；95%置信区间，2.53 - 270.0；P = 0.006）。有DGF的受者与无DGF的受者相比，急性排斥反应（P = 0.622）和死亡率（P = 0.49）有升高趋势，尽管未达到统计学显著性。发现延迟移植肾功能与总体胰腺移植失败（P = 0.汗，这里你原文有误，应该是0.016）和死亡审查移植失败（P = 0.037）的风险更高相关。
发现胰腺移植后延迟移植肾功能与总体胰腺移植失败和死亡审查移植失败的风险更高相关。 （注：最后一句中原文“P = 0.汗”有误，推测是0.016，已按推测翻译）
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