Czitrom A A, Pototschnik R, Edwards S, Gladman D D, Falk J A
Department of Surgery, University of Toronoto, Ont., Canada.
Exp Clin Immunogenet. 1986;3(3):129-37.
We have generated several human alloreactive cytolytic T lymphocyte (CTL) clones specific for HLA B27 expressed on cells of normals or of patients with ankylosing spondylitis (AS). These clonal T cell reagents were used to test the recognition of panels of target cells from B27+AS+, B27+AS- and B27- individuals. None of these CTL clones distinguished differences between B27+AS+ and B27+AS- cells. Three clones recognized subtypes of HLA B27 and two of these were cytolytic with group-reactive epitopes of other HLA antigens. The results suggest that there are no immunogenic disease-specific epitopes of HLA B27 in B27-linked spondyloarthropathy.
我们已生成了多个针对正常个体或强直性脊柱炎（AS）患者细胞上表达的HLA B27的人同种异体反应性细胞毒性T淋巴细胞（CTL）克隆。这些克隆性T细胞试剂用于测试来自B27 + AS +、B27 + AS - 和B27 - 个体的靶细胞面板的识别情况。这些CTL克隆均未区分B27 + AS + 和B27 + AS - 细胞之间的差异。三个克隆识别HLA B27的亚型，其中两个对其他HLA抗原的群体反应性表位具有细胞毒性。结果表明，在B27相关的脊柱关节病中，不存在HLA B27的免疫原性疾病特异性表位。
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