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Small-molecule SMAC mimetics as new cancer therapeutics.
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SMAC Mimetics Induce Autophagy-Dependent Apoptosis of HIV-1-Infected Resting Memory CD4+ T Cells.
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Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.
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Smac mimetics in combination with TRAIL selectively target cancer stem cells in nasopharyngeal carcinoma.
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Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2.
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Design of small-molecule Smac mimetics as IAP antagonists.
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Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs.
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Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.
Cell Death Differ. 2011 Aug;18(8):1376-86. doi: 10.1038/cdd.2011.10. Epub 2011 Feb 18.
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Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression.
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11936-41. doi: 10.1073/pnas.1005667107. Epub 2010 Jun 14.

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Multidrug Resistance: Are We Still Afraid of the Big Bad Wolf.
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Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection.
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Macrophage regulated cell death: implications and mechanisms in organ transplantation.
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Parthanatos and apoptosis: unraveling their roles in cancer cell death and therapy resistance.
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2
Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis.
Cell Death Dis. 2013 Nov 28;4(11):e936. doi: 10.1038/cddis.2013.457.
3
Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity.
Cell Death Dis. 2013 Nov 14;4(11):e920. doi: 10.1038/cddis.2013.449.
4
Targeting apoptosis pathways for new cancer therapeutics.
Annu Rev Med. 2014;65:139-55. doi: 10.1146/annurev-med-010713-141310. Epub 2013 Nov 4.
5
IAP proteins as targets for drug development in oncology.
Onco Targets Ther. 2013 Sep 16;9:1285-304. doi: 10.2147/OTT.S33375.
7
IAPs on the move: role of inhibitors of apoptosis proteins in cell migration.
Cell Death Dis. 2013 Sep 5;4(9):e784. doi: 10.1038/cddis.2013.311.
8
Signaling networks of Rho GTPases in cell motility.
Cell Signal. 2013 Oct;25(10):1955-61. doi: 10.1016/j.cellsig.2013.04.009. Epub 2013 May 11.
9
The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells.
Clin Cancer Res. 2013 Apr 1;19(7):1784-94. doi: 10.1158/1078-0432.CCR-12-2518. Epub 2013 Feb 12.
10
Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation.
Cancer Discov. 2013 Feb;3(2):212-23. doi: 10.1158/2159-8290.CD-12-0271. Epub 2012 Dec 26.

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