Chowdhury Tumul, Kowalski Stephen, Arabi Yaseen, Dash Hari Hara
Department of Anesthesiology and Perioperative Medicine, Section of Critical Care, University of Manitoba, Winnipeg, Canada.
Department of Intensive Care, King Abdul-Aziz Medical City, Riyadh, Kingdom of Saudi Arabia.
Saudi J Anaesth. 2014 Apr;8(2):256-63. doi: 10.4103/1658-354X.130742.
Traumatic brain injury (TBI) is a growing epidemic throughout the world and may present as major global burden in 2020. Some intensive care units throughout the world still have no access to specialized monitoring methods, equipments and other technologies related to intensive care management of these patients; therefore, this review is meant for providing generalized supportive measurement to this subgroup of patients so that evidence based management could minimize or prevent the secondary brain injury.
Therefore, we have included the PubMed search for the relevant clinical trials and reviews (from 1 January 2007 to 31 March 2013), which specifically discussed about the topic.
General supportive measures are equally important to prevent and minimize the effects of secondary brain injury and therefore, have a substantial impact on the outcome in patients with TBI. The important considerations for general supportive intensive care unit care remain the prompt reorganization and treatment of hypoxemia, hypotension and hypercarbia. Evidences are found to be either against or weak regarding the use of routine hyperventilation therapy, tight control blood sugar regime, use of colloids and late as well as parenteral nutrition therapy in patients with severe TBI.
There is also a need to develop some evidence based protocols for the health-care sectors, in which there is still lack of specific management related to monitoring methods, equipments and other technical resources. Optimization of physiological parameters, understanding of basic neurocritical care knowledge as well as incorporation of newer guidelines would certainly improve the outcome of the TBI patients.
创伤性脑损伤(TBI)在全球范围内呈日益流行之势,到2020年可能成为重大的全球负担。世界各地的一些重症监护病房仍然无法获得与这些患者的重症监护管理相关的专业监测方法、设备及其他技术;因此,本综述旨在为这一亚组患者提供一般性的支持措施,以便基于证据的管理能够将继发性脑损伤降至最低或加以预防。
因此,我们纳入了对相关临床试验和综述的PubMed检索(从2007年1月1日至2013年3月31日),这些文献专门讨论了该主题。
一般性支持措施对于预防和减轻继发性脑损伤的影响同样重要,因此对TBI患者的预后有重大影响。重症监护病房一般性支持治疗的重要考量因素仍然是及时纠正和治疗低氧血症、低血压和高碳酸血症。关于在重度TBI患者中使用常规过度通气疗法、严格控制血糖方案、使用胶体以及晚期和肠外营养疗法,证据显示要么不利,要么薄弱。
对于仍然缺乏与监测方法、设备及其他技术资源相关的具体管理措施的医疗保健部门,也有必要制定一些基于证据的方案。优化生理参数、了解基本的神经重症监护知识以及纳入更新的指南肯定会改善TBI患者的预后。