双侧脚趾和足底麻木和感觉异常，以及仅限于面部和躯干的不成比例的出汗，是诊断糖尿病对称性多发性神经病的有用症状。
Numbness and paresthesia in bilateral toes and soles, and disproportional sweating restricted to face and trunk are suitable symptoms useful for the diagnosis of diabetic symmetric polyneuropathy.
机构信息
First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
出版信息
J Diabetes Investig. 2011 Nov 30;2(6):464-73. doi: 10.1111/j.2040-1124.2011.00124.x.
UNLABELLED
Aims/Introduction: In order to diagnose diabetic symmetric polyneuropathy (DSPN) more simply and accurately, we identified symptoms that correlated with neurological functions and existed more frequently in diabetic than non-diabetic subjects.
MATERIALS AND METHODS
The relationships between 10 symptoms (numbness or paresthesia in toe and sole, numbness in hand, pain in foot or hand, coldness in legs, painful leg cramp, dizziness on standing, sweating restricted to face/trunk and frequent constipation/diarrhea) and clinical background, defined as DSPN and cardiovascular autonomic neuropathy (CAN) by the criteria proposed in the statement of the American Diabetes Association, and seven quantitative nerve function data were evaluated in 593 diabetic patients in Wakayama Medical University Hospital (WMUH). Furthermore, the prevalence of various symptoms was examined by three questionnaires: a WMUH survey (999 diabetic outpatients), a Nationwide survey (1524 male diabetic outpatients under a primary-care physician) and a Control survey (501 non-diabetic subjects).
RESULTS
Bilateral 'numbness in toe and sole', 'paresthesia in toe and sole', 'pain in foot' and 'sweating restricted to face/trunk' were significantly associated with diabetes duration, retinopathy, probable and confirmed DSPN, possible and advanced CAN, and all or six nerve functions. Questionnaire surveys clarified that symptoms that are not rare (>15%) and more frequent in diabetic than non-diabetic subjects were bilateral 'numbness in toe and sole', 'paresthesia in toe and sole', 'coldness in legs', 'dizziness on standing' and 'sweating restricted to face/trunk'.
CONCLUSIONS
Therefore, bilateral 'numbness in toe and sole', 'paresthesia in toe and sole' and 'sweating restricted to face/trunk' are suitable symptoms useful for the diagnosis of DSPN. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2011.00124.x, 2011).
目的/引言：为了更简单、更准确地诊断糖尿病对称性多发性神经病（DSPN），我们确定了与神经功能相关且在糖尿病患者中比非糖尿病患者更常见的症状。
材料和方法
在和歌山医科大学医院（WMUH）的 593 例糖尿病患者中，评估了 10 种症状（脚趾和足底麻木或感觉异常、手部麻木、足部或手部疼痛、腿部发冷、腿部痉挛性疼痛、站立时头晕、仅面部/躯干出汗、经常便秘/腹泻）与临床背景（由美国糖尿病协会的声明中定义的 DSPN 和心血管自主神经病变（CAN））之间的关系，临床背景还包括七个定量神经功能数据。此外，通过三种问卷检查了各种症状的患病率：WMUH 调查（999 例糖尿病门诊患者）、全国调查（1524 例初级保健医生管理的男性糖尿病门诊患者）和对照调查（501 例非糖尿病患者）。
结果
双侧“脚趾和足底麻木”、“脚趾和足底感觉异常”、“足部疼痛”和“仅面部/躯干出汗”与糖尿病病程、视网膜病变、可能和确诊的 DSPN、可能和进展的 CAN 以及所有或六种神经功能显著相关。问卷调查结果表明，在糖尿病患者中并不罕见（>15%）且比非糖尿病患者更常见的症状有双侧“脚趾和足底麻木”、“脚趾和足底感觉异常”、“腿部发冷”、“站立时头晕”和“仅面部/躯干出汗”。
结论
因此，双侧“脚趾和足底麻木”、“脚趾和足底感觉异常”和“仅面部/躯干出汗”是诊断 DSPN 的合适症状。（《糖尿病研究与临床实践》，doi:10.1111/j.2040-1124.2011.00124.x，2011）。
Zotero 插件