整合素β6作为滤泡性甲状腺癌肿瘤复发因素的临床意义

Clinical significance of integrin β6 as a tumor recurrence factor in follicular thyroid carcinoma.

作者信息

Zhuang Zhuo-nan, Xu Zhen-jie, Zhou Qian, Xu Xiao-zhou, Tian Jessie, Liu Yan-feng, Guo Sen, Wang Jia-yong, Xu Ke-sen

机构信息

Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Shandong, People's Republic of China.

Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Shandong, People's Republic of China.

出版信息

Head Neck. 2015 Oct;37(10):1439-47. doi: 10.1002/hed.23780. Epub 2014 Jul 21.

DOI:10.1002/hed.23780

PMID:24844802

Abstract

BACKGROUND

Overexpression of integrin β6 plays an important role in a variety of malignant tumor invasion and metastasis.

METHODS

The expression levels of integrin β6, matrix metalloproteinase (MMP)-2 and MMP-9 were analyzed by immunohistochemistry with human follicular thyroid carcinomas. Then we investigated their correlation with clinical outcomes parameters, relationship, and the survival time.

RESULTS

The integrin β6 staining was expressed in cellular membrane and cytoplasm of follicular thyroid carcinoma cells. The MMP-2 and MMP-9 expressions were mainly found in cellular cytoplasm. In correlation with the clinical outcome parameters of 60 patients, there were significant statistical differences of integrin β6, MMP-2, and MMP-9 expression levels in different size of tumor. Integrin β6 and MMP-9 expressions have significant statistical differences in T classifications. MMP-2 and MMP-9 expressions have significant statistical differences in different M classification. Other clinical outcome parameters had no significant statistical differences.

CONCLUSION

Integrin β6 expression correlated significantly with MMP-9 expression, and may be a valuable recurrence indicator for follicular thyroid carcinomas.

摘要

背景

整合素β6的过表达在多种恶性肿瘤的侵袭和转移中起重要作用。

方法

采用免疫组织化学方法分析人甲状腺滤泡癌中整合素β6、基质金属蛋白酶（MMP）-2和MMP-9的表达水平。然后研究它们与临床结局参数的相关性、关系及生存时间。

结果

整合素β6染色表达于甲状腺滤泡癌细胞的细胞膜和细胞质中。MMP-2和MMP-9的表达主要见于细胞质中。与60例患者的临床结局参数相关分析显示，不同肿瘤大小的整合素β6、MMP-2和MMP-9表达水平存在显著统计学差异。整合素β6和MMP-9的表达在T分类中有显著统计学差异。MMP-2和MMP-9的表达在不同M分类中有显著统计学差异。其他临床结局参数无显著统计学差异。