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一项前瞻性妊娠队列研究中从孕早期至产后4年的产妇抑郁:对初级卫生保健的启示

Maternal depression from early pregnancy to 4 years postpartum in a prospective pregnancy cohort study: implications for primary health care.

作者信息

Woolhouse H, Gartland D, Mensah F, Brown S J

机构信息

Healthy Mothers Healthy Families, Murdoch Childrens Research Institute and Royal Children's Hospital, Parkville, Vic., Australia.

出版信息

BJOG. 2015 Feb;122(3):312-21. doi: 10.1111/1471-0528.12837. Epub 2014 May 21.

Abstract

OBJECTIVE

To describe the prevalence of maternal depression from pregnancy to 4 years postpartum, and the risk factors for depressive symptoms at 4 years postpartum.

DESIGN

Prospective pregnancy cohort study of nulliparous women.

SETTING

Melbourne, Australia.

SAMPLE

In all, 1507 women completed baseline data in pregnancy (mean gestation 15 weeks).

METHODS

Women were recruited from six public hospitals. Questionnaires were completed at recruitment and 3, 6, 12 and 18 months postpartum, and 4 years postpartum.

MAIN OUTCOME MEASURES

Scores ≥13 on the Edinburgh Postnatal Depression Scale were used to indicate depressive symptoms.

RESULTS

Almost one in three women reported depressive symptoms at least once in the first 4 years after birth. The prevalence of depressive symptoms at 4 years postpartum was 14.5%, and was higher than at any time-point in the first 12 months postpartum. Women with one child at 4 years postpartum were more likely to report depressive symptoms at this time compared with women with subsequent children (22.9 versus 11.3%), and this association remained significant in adjusted models (Adjusted odds ratio 1.71, 95% confidence interval 1.12-2.63).

CONCLUSIONS

Maternal depression is more common at 4 years postpartum than at any time in the first 12 months postpartum, and women with one child at 4 years postpartum report significantly higher levels of depressive symptoms than women with subsequent children. There is a need for scaling up of current services to extend surveillance of maternal mental health to cover the early years of parenting.

摘要

目的

描述从孕期到产后4年的孕产妇抑郁患病率,以及产后4年抑郁症状的危险因素。

设计

对未生育女性进行的前瞻性妊娠队列研究。

地点

澳大利亚墨尔本。

样本

共有1507名女性在孕期完成了基线数据收集(平均孕周15周)。

方法

从6家公立医院招募女性。在招募时、产后3个月、6个月、12个月、18个月及4年时完成问卷调查。

主要观察指标

使用爱丁堡产后抑郁量表得分≥13分来表明存在抑郁症状。

结果

近三分之一的女性在产后头4年至少有一次报告有抑郁症状。产后4年抑郁症状的患病率为14.5%,高于产后头12个月的任何时间点。产后4年育有一个孩子的女性此时比育有多个孩子的女性更有可能报告有抑郁症状(22.9%对11.3%),在调整模型中这种关联仍然显著(调整后的优势比为1.71,95%置信区间为1.12 - 2.63)。

结论

产后4年的孕产妇抑郁比产后头12个月的任何时候都更常见,产后4年育有一个孩子的女性报告的抑郁症状水平显著高于育有多个孩子的女性。有必要扩大现有服务,将孕产妇心理健康监测扩展至育儿早期阶段。

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