Affiliations of authors: Unit of Virus, Lifestyle and Genes (LB, SKK), Unit of Statistics, Bioinformatics and Registry (SF, CD, KKA), and Directors Office (JHO), Danish Cancer Society Research Center, Copenhagen, Denmark; Gynecologic Clinic, the Juliane Marie Center, Rigshospitalet, University of Copenhagen, Denmark (SKK).
J Natl Cancer Inst. 2014 May 21;106(6):dju111. doi: 10.1093/jnci/dju111. Print 2014 Jun.
It has been suggested that paracetamol reduces the risk for ovarian cancer. We examined the association between prescription use of paracetamol and ovarian cancer risk in a nationwide case-control study nested within the Danish female population. Case patients (n = 3471) were all women with a first diagnosis of epithelial ovarian cancer during the period from 2000 to 2009. Population control subjects (n = 50576) were selected by risk set sampling. Data were derived from prescription and other nationwide registries. Conditional logistic regression was used to estimate odds ratios (ORs) and two-sided 95% confidence intervals (CIs) for ovarian cancer associated with use of paracetamol or nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs). All statistical tests were two-sided. Use of paracetamol was associated with a reduced odds ratio for ovarian cancer (OR = 0.82; 95% CI = 0.74 to 0.92; P < .001) compared with nonuse, and the odds ratio decreased further with long-term (≥10 years), high-intensity paracetamol use (OR = 0.45; 95% CI = 0.24 to 0.86; P = .02). Use of nonaspirin NSAIDs was not associated with ovarian cancer risk.
有人认为对乙酰氨基酚可降低卵巢癌的发病风险。我们通过巢式病例对照研究，在丹麦女性人群中，调查了处方使用对乙酰氨基酚与卵巢癌风险之间的相关性。病例患者（n = 3471）均为 2000 年至 2009 年期间初次诊断为上皮性卵巢癌的女性。人群对照受试者（n = 50576）通过风险集抽样选择。数据来自处方和其他全国性登记处。采用条件 logistic 回归来估计与使用对乙酰氨基酚或非阿司匹林非甾体抗炎药（NSAIDs）相关的卵巢癌的比值比（OR）和双侧 95%置信区间（CI）。所有统计检验均为双侧。与不使用者相比，使用对乙酰氨基酚与卵巢癌的比值比降低（OR = 0.82；95%CI = 0.74 至 0.92；P <.001），长期（≥10 年）、高强度使用对乙酰氨基酚的比值比进一步降低（OR = 0.45；95%CI = 0.24 至 0.86；P =.02）。使用非阿司匹林 NSAIDs 与卵巢癌风险无关。
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