慢性乙型肝炎患者使用干扰素治疗期间的干扰素受体

Interferon receptors during treatment of chronic hepatitis B with interferon.

作者信息

Nakajima S, Kuroki T, Kurai O, Kobayashi K, Yamamoto S

机构信息

Third Department of Internal Medicine, Osaka City University Medical School, Japan.

出版信息

J Gastroenterol Hepatol. 1989 Sep-Oct;4(5):419-27. doi: 10.1111/j.1440-1746.1989.tb01739.x.

DOI:10.1111/j.1440-1746.1989.tb01739.x

PMID:2485010

Abstract

The in vitro binding of 125I-labelled human alpha-interferon to peripheral blood mononuclear cells from 13 patients with chronic hepatitis B during interferon therapy was assayed in order to identify changes in the number of interferon receptors during treatment. Nine patients were treated with human alpha-interferon (Hu alpha-IFN) or human beta-interferon (Hu beta-IFN) daily for 4 weeks. During therapy, receptor sites per cell decreased by 40%. Two weeks after therapy ceased, this number had returned to the pretreatment level. The other four patients were given Hu alpha-IFN daily for 2 weeks, no injections for 2 weeks, and daily injections for 2 weeks. During both periods of therapy, receptor sites decreased by 40%. The number increased to 94% of the pretreatment level 1 week after the first period and to 101% 2 weeks later. It was 80% 1 week after the second period of injections and 108% 2 weeks later.

摘要

为了确定治疗期间干扰素受体数量的变化，对13例慢性乙型肝炎患者在干扰素治疗期间外周血单个核细胞与125I标记的人α干扰素的体外结合进行了检测。9例患者每天接受人α干扰素（Huα-IFN）或人β干扰素（Huβ-IFN）治疗，持续4周。治疗期间，每个细胞的受体位点减少了40%。治疗停止两周后，这个数字已恢复到治疗前水平。另外4例患者每天接受Huα-IFN治疗2周，停药2周，然后再每天注射2周。在两个治疗阶段，受体位点均减少了40%。在第一个治疗阶段后1周，该数字增加到治疗前水平的94%，2周后增加到101%。在第二个注射阶段后1周为80%，2周后为108%。