Höög Charlotte M, Bark Lars-Åke, Broström Olle, Sjöqvist Urban
Department for Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Section for Gastroenterology and Hepatology , Stockholm , Sweden.
Scand J Gastroenterol. 2014 Sep;49(9):1084-90. doi: 10.3109/00365521.2014.920915. Epub 2014 May 22.
Capsule endoscopy (CE) is a sensitive method for detecting inflammatory lesions in the small bowel. Such lesions may be due to Crohn's disease but also to other causes and a histological diagnosis may be difficult to achieve in the small bowel. The aim of the study was to find a possible correlation between capsule endoscopic findings, biochemical parameters, and symptoms in patients with suspected or known small-bowel Crohn´s disease.
Thirty patients with inflammatory lesions in the small bowel diagnosed by CE were included. CE findings of inflammation were graded using the Lewis score. C-reactive protein (CRP) and fecal calprotectin were used as biochemical parameters. Symptoms were graded using the Harvey-Bradshaw index. The patients were followed up after 9 months with a second CE, CRP, fecal calprotectin, and Harvey-Bradshaw index.
There was a significant persistent correlation between endoscopic inflammation and fecal calprotectin (p = 0.003 at inclusion and p < 0.001 at follow-up). CRP was correlated to endoscopic inflammation at inclusion (p = 0.006), but not at follow-up. Symptoms were not correlated with endoscopic inflammation.
Inflammatory lesions in the small bowel diagnosed by CE in patients with suspected Crohn´s disease are correlated to fecal calprotectin and CRP, but not to symptoms.
胶囊内镜检查（CE）是检测小肠炎症性病变的一种敏感方法。此类病变可能由克罗恩病引起，但也可能由其他原因导致，小肠的组织学诊断可能难以实现。本研究的目的是在疑似或已知小肠克罗恩病患者中寻找胶囊内镜检查结果、生化参数和症状之间可能存在的相关性。
纳入30例经CE诊断为小肠炎症性病变的患者。炎症的CE检查结果采用Lewis评分进行分级。C反应蛋白（CRP）和粪便钙卫蛋白用作生化参数。症状采用Harvey-Bradshaw指数进行分级。9个月后对患者进行第二次CE检查、CRP、粪便钙卫蛋白和Harvey-Bradshaw指数检查以进行随访。
内镜下炎症与粪便钙卫蛋白之间存在显著的持续相关性（纳入时p = 0.003，随访时p < 0.001）。CRP在纳入时与内镜下炎症相关（p = 0.006），但在随访时不相关。症状与内镜下炎症不相关。
疑似克罗恩病患者经CE诊断的小肠炎症性病变与粪便钙卫蛋白和CRP相关，但与症状无关。
