Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Calle 43 No. 130, Col. Chuburná de Hidalgo, C.P. 97200 Mérida, Yucatán, Mexico.
Centro de Biomateriales, Universidad de la Habana, Avenida Universidad, s/n, e/G y Ronda, C.P. 10600 C. de La Habana, Cuba.
Mater Sci Eng C Mater Biol Appl. 2014 Jul 1;40:157-63. doi: 10.1016/j.msec.2014.03.064. Epub 2014 Mar 31.
The aim of this work was to provide some fundamental information for optimization of silanization of hydroxyapatite intended for bone cement formulations. The effect of 3-(trimethoxysilyl) propyl methacrylate (MPS) concentration and solvent system (acetone/water or methanol/water mixtures) during HA silanization was monitored by X-ray diffraction (XRD), FTIR spectroscopy and EDX analysis. The effect of silanized HA on the mechanical properties of acrylic bone cements is also reported. It was found that the silanization process rendered hydroxyapatite with lower crystallinity compared to untreated HA. Through EDX, it was observed that the silicon concentration in the HA particles was higher for acetone-water than that obtained for methanol-water system, although the mechanical performance of cements prepared with these particles exhibited the opposite behavior. Taking all these results together, it is concluded that methanol-water system containing MPS at 3wt.% provides the better results during silanization process of HA.
本工作旨在为优化用于骨水泥制剂的羟基磷灰石硅烷化提供一些基本信息。通过 X 射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和 EDX 分析监测了 3-（三甲氧基硅基）丙基甲基丙烯酸酯（MPS）浓度和溶剂体系（丙酮/水或甲醇/水混合物）对 HA 硅烷化的影响。还报告了硅烷化 HA 对丙烯酸骨水泥力学性能的影响。结果发现，与未处理的 HA 相比，硅烷化过程使羟基磷灰石的结晶度降低。通过 EDX 观察到，尽管用这些颗粒制备的水泥表现出相反的行为，但在丙酮-水中 HA 颗粒中的硅浓度高于在甲醇-水中获得的硅浓度。综合所有这些结果，可以得出结论，在 HA 的硅烷化过程中，甲醇-水体系中含有 3wt.%的 MPS 可提供更好的结果。
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