Munsie Megan, Hyun Insoo
Stem Cells Australia, Department of Anatomy and Neuroscience, The University of Melbourne, Parkville 3010, Australia.
Department of Bioethics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-4976, USA.
Stem Cell Res. 2014 Nov;13(3 Pt B):647-53. doi: 10.1016/j.scr.2014.04.014. Epub 2014 Apr 29.
The idea that the body's own stem cells could act as a repair kit for many conditions, including cardiac repair, underpins regenerative medicine. While progress is being made, with hundreds of clinical trials underway to evaluate possible autologous cell-based therapies, some patients and physicians are not prepared to wait and are pursuing treatments without evidence that the proposed treatments are effective, or even safe. This article explores the inherent tension between patients, practitioners and the need to regulate the development and commercialization of new cellular therapies--even when the cells come from the patient.
人体自身的干细胞可以充当治疗多种疾病（包括心脏修复）的修复工具，这一理念是再生医学的基础。虽然目前正在取得进展，有数百项临床试验正在进行，以评估可能的自体细胞疗法，但一些患者和医生不愿等待，在没有证据证明所提议的治疗方法有效甚至安全的情况下就寻求治疗。本文探讨了患者、从业者之间的内在矛盾，以及对新细胞疗法的开发和商业化进行监管的必要性——即使这些细胞来自患者自身。
