电压门控钙通道的钙调蛋白调节（钙调制）
Calmodulin regulation (calmodulation) of voltage-gated calcium channels.
作者信息
Ben-Johny Manu, Yue David T
机构信息
Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
出版信息
J Gen Physiol. 2014 Jun;143(6):679-92. doi: 10.1085/jgp.201311153.
Calmodulin regulation (calmodulation) of the family of voltage-gated CaV1-2 channels comprises a prominent prototype for ion channel regulation, remarkable for its powerful Ca(2+) sensing capabilities, deep in elegant mechanistic lessons, and rich in biological and therapeutic implications. This field thereby resides squarely at the epicenter of Ca(2+) signaling biology, ion channel biophysics, and therapeutic advance. This review summarizes the historical development of ideas in this field, the scope and richly patterned organization of Ca(2+) feedback behaviors encompassed by this system, and the long-standing challenges and recent developments in discerning a molecular basis for calmodulation. We conclude by highlighting the considerable synergy between mechanism, biological insight, and promising therapeutics.
电压门控CaV1-2通道家族的钙调蛋白调节（钙调制）是离子通道调节的一个突出范例，以其强大的Ca(2+) 传感能力、深刻精妙的机制教训以及丰富的生物学和治疗学意义而著称。因此，该领域处于Ca(2+) 信号生物学、离子通道生物物理学和治疗进展的核心位置。本综述总结了该领域思想的历史发展、该系统所包含的Ca(2+) 反馈行为的范围和丰富的模式化组织，以及在识别钙调制分子基础方面长期存在的挑战和最新进展。我们通过强调机制、生物学见解和有前景的治疗方法之间的显著协同作用来得出结论。
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