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[活体供肝肝移植患者的围手术期管理]

[Perioperative management of patients for living-donor liver transplantation].

作者信息

Matsumoto Atsuhiro, Fujino Yuji

出版信息

Masui. 2014 May;63(5):528-33.

Abstract

Living-donor liver transplantation has become a standard and effective treatment for end stage liver disease patients. As a result of remarkable progress in immunosuppressive drugs, surgical device, anesthetics, and appropriate perioperative management, liver-transplanted patients may experience fewer complications, shorter length of ICU stay, and a better overall outcome. However, unexpected perioperative complications remain substantial. Therefore, we take care in several points in perioperative period. First, we should appropriately evaluate general preoperative conditions, such as coagulopathy, ascites, respiratory and renal function. Second, we need to maintain hemodynamic stabilization, electrolyte balance, correction of coagulopathy and prevention of portal hypertention during operation. And third, in postoperative period we should perform strict monitoring and focus on infection prophylaxis, early weaning from mechanical ventilation, appropriate administration of fluid and transfusion, maintaining renal function and preservation of graft function. Appropriate knowledge and understanding of perioperative management in liver transplantation are required to improve patient's outcome. Furthermore, it is important for performing liver transplantation to boost mutual understanding and trust in the medical team including health-care providers.

摘要

活体肝移植已成为终末期肝病患者的一种标准且有效的治疗方法。由于免疫抑制药物、手术器械、麻醉以及适当的围手术期管理取得了显著进展,肝移植患者可能会出现更少的并发症、更短的重症监护病房住院时间以及更好的总体预后。然而,围手术期意外并发症仍然相当多。因此,我们在围手术期要注意几个方面。首先,我们应适当评估术前的一般状况,如凝血功能障碍、腹水、呼吸和肾功能。其次,我们需要在手术期间维持血流动力学稳定、电解质平衡、纠正凝血功能障碍并预防门静脉高压。第三,在术后阶段,我们应进行严格监测,并着重预防感染、尽早脱机、适当补液和输血、维持肾功能以及保护移植物功能。为改善患者预后,需要对肝移植围手术期管理有适当的认识和理解。此外,对于进行肝移植而言,增进包括医护人员在内的医疗团队之间的相互理解和信任也很重要。

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