甲状旁腺激素相关蛋白在骨骼和软骨代谢中的作用
[Role for PTHrP in bone and cartilage metabolism].
作者信息
Inoue Daisuke
机构信息
Third Department of Medicine, Teikyo University Chiba Medical Center, Japan.
出版信息
Clin Calcium. 2014 Jun;24(6):863-9.
PMID:24870837
Abstract
PTH-related peptide (PTHrP) is a widely distributed cytokine, which shares the cognate receptor PTHR1 with PTH. Originally identified as a causal factor of humoral hypercalcemia of malignancy twenty years ago, PTHrP is now recognized as a critical physiological regulator of various biological processes, including bone and cartilage metabolism.
摘要
甲状旁腺激素相关肽（PTHrP）是一种广泛分布的细胞因子，它与甲状旁腺激素（PTH）共用同源受体PTHR1。二十年前，PTHrP最初被确定为恶性肿瘤体液性高钙血症的致病因素，现在它被认为是包括骨和软骨代谢在内的各种生物过程的关键生理调节因子。
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