时空变化性视幻觉：I. 皮质丘脑理论。
Spatiotemporally varying visual hallucinations: I. Corticothalamic theory.
作者信息
Henke H, Robinson P A, Drysdale P M, Loxley P N
机构信息
School of Physics, The University of Sydney, Sydney, New South Wales 2006, Australia; Brain Dynamics Center, Westmead Millennium Institute, The University of Sydney, Westmead, New South Wales 2145, Australia.
School of Physics, The University of Sydney, Sydney, New South Wales 2006, Australia; Brain Dynamics Center, Westmead Millennium Institute, The University of Sydney, Westmead, New South Wales 2145, Australia; Center for Integrative Brain Function, University of Sydney, New South Wales 2006, Australia; Center for Integrative Research and Understanding of Sleep, 431 Glebe Point Rd., Glebe, New South Wales 2037, Australia; Cooperative Research Center for Alertness, Sleep, and Productivity, University of Sydney, New South Wales 2006, Australia; Neurosleep, 431 Glebe Point Rd., Glebe, New South Wales 2037, Australia.
出版信息
J Theor Biol. 2014 Sep 21;357:200-9. doi: 10.1016/j.jtbi.2014.05.025. Epub 2014 May 27.
The thalamus is introduced to a recent model of the visual cortex to examine its effect on pattern formation in general and the generation of temporally oscillating patterns in particular. By successively adding more physiological details to a basic corticothalamic model, it is determined which features are responsible for which effects. In particular, with the addition of a thalamic population, several changes occur in the spatiotemporal power spectrum: power increases at resonances of the corticothalamic loop, while the loop acts as a spatiotemporal low-pass filter, and synaptic and dendritic dynamics temporally low-pass filter the activity more generally. Investigation of the effect of altering parameters and gains reveals new parameter regimes where activity that corresponds to hallucinations is induced by both spatially homogeneous and inhomogeneous temporally oscillating modes. This suggests that the thalamus and corticothalamic loops are essential components of a model of oscillating visual hallucinations.
丘脑被引入到最近的视觉皮层模型中，以研究其对一般模式形成的影响，特别是对时间振荡模式产生的影响。通过在基本的皮质丘脑模型中依次添加更多生理细节，确定了哪些特征导致了哪些影响。特别是，随着丘脑神经元群体的加入，时空功率谱发生了几个变化：在皮质丘脑环路的共振频率处功率增加，而该环路起到了时空低通滤波器的作用，并且突触和树突动力学在更一般的情况下对活动进行时间低通滤波。对改变参数和增益的影响进行研究后发现了新的参数范围，在这些范围内，空间均匀和不均匀的时间振荡模式都会诱发与幻觉相对应的活动。这表明丘脑和皮质丘脑环路是振荡性视幻觉模型的重要组成部分。
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