接受司他夫定治疗的儿童的周围神经病变。

Peripheral neuropathy in children on stauvudine therapy.

作者信息

Sankhyan Naveen, Lodha Rakesh, Sharma Suvasini, Menon P Ramesh, Choudhary Anita, Kabra Sushil K, Gulati Sheffali

机构信息

Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India.

出版信息

Indian J Pediatr. 2015 Feb;82(2):136-9. doi: 10.1007/s12098-014-1477-5. Epub 2014 May 31.

DOI:10.1007/s12098-014-1477-5

PMID:24874810

Abstract

OBJECTIVE

To assess the prevalence of peripheral neuropathy in HIV infected children (>5 y) receiving stavudine-based combination anti-retroviral treatment (ART) for more than 3 mo in a cross-sectional study.

METHODS

History, detailed neurological examination and nerve conduction studies were performed.

RESULTS

Forty children [26 boys; median age - 11.75 y, Inter quartile range (IQR): 9-16 y] were enrolled. The median duration of ART was 43 mo [IQR: 18-69 mo]. The nerve conduction studies were abnormal in four children (10 %). Symptomatic distal sensory polyneuropathy was present in two children, asymptomatic distal sensory polyneuropathy and subclinical distal sensory polyneuropathy was present in one child each.

CONCLUSIONS

Distal sensory polyneuropathy is a potential problem in children on stavudine based ART. Children on stavudine based ART need periodic clinical and electrophysiological screening for its early detection.

摘要

目的

在一项横断面研究中，评估接受基于司他夫定的联合抗逆转录病毒治疗（ART）超过3个月的HIV感染儿童（>5岁）外周神经病变的患病率。

方法

进行病史采集、详细的神经系统检查和神经传导研究。

结果

共纳入40名儿童[26名男孩；中位年龄-11.75岁，四分位间距（IQR）：9-16岁]。ART的中位持续时间为43个月[IQR：18-69个月]。4名儿童（10%）的神经传导研究异常。2名儿童存在有症状的远端感觉性多发性神经病变，1名儿童存在无症状的远端感觉性多发性神经病变，另1名儿童存在亚临床远端感觉性多发性神经病变。