Shi Yufeng, Lim S Kyun, Parada Luis F
Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Cell Res. 2014 Aug;24(8):910-1. doi: 10.1038/cr.2014.72. Epub 2014 May 30.
In a recent Cell paper, Kitambi and colleagues identify a small molecule (Vacquinol-1) that has beneficial effects on a glioblastoma multiforme mouse model by oral administration. In glioblastoma cells, Vacquinol-1 targets macropinocytosis, a cellular process that will not lead to cell death in normal cells.
在最近发表于《细胞》杂志的一篇论文中,基坦比及其同事鉴定出一种小分子(Vacquinol-1),通过口服给药对多形性胶质母细胞瘤小鼠模型具有有益作用。在胶质母细胞瘤细胞中,Vacquinol-1靶向巨胞饮作用,这是一种在正常细胞中不会导致细胞死亡的细胞过程。