Yücel Y H, Jardon B, Bonaventure N
Département de Neurophysiologie et de Biologie des Comportements, Centre de Neurochimie du CNRS, Strasbourg, France.
Vis Neurosci. 1989;2(4):357-65. doi: 10.1017/s0952523800002169.
The specific role of ON and OFF retinal information channels in the generation of the horizontal optokinetic nystagmus (OKN) of the frog was studied. Coil recordings of monocular eye and head OKN were obtained before and after intravitreal injection of two drugs that block either ON or OFF channels. The intravitreal injection of 2-amino-4-phosphonobutyrate (APB), a glutamate analog that selectively blocks the ON retinal channel, strongly reduced or even cancelled the monocular OKN of the head and of the eye. The intravitreal injection of another glutamate analog, the cis-2,3-piperidine dicarboxylic acid (PDA) that especially blocks the OFF retinal channel, did not affect the gain velocity of the slow phase of both the horizontal monocular head and eye OKN, for low stimulus velocities. Our results suggest that the retinal ON information channel, but not the OFF channel, is involved in the generation of the slow phase of the OKN of the frog, at least at low drum velocities.
研究了视网膜开（ON）和关（OFF）信息通道在青蛙水平视动性眼震（OKN）产生中的具体作用。在玻璃体内注射两种分别阻断ON或OFF通道的药物之前和之后，获得了单眼眼球和头部OKN的线圈记录。玻璃体内注射2-氨基-4-膦酰丁酸（APB），一种选择性阻断视网膜ON通道的谷氨酸类似物，强烈降低甚至消除了头部和眼球的单眼OKN。玻璃体内注射另一种谷氨酸类似物顺式-2,3-哌啶二羧酸（PDA），其特别阻断视网膜OFF通道，对于低刺激速度，并未影响水平单眼头部和眼球OKN慢相的增益速度。我们的结果表明，至少在低鼓速下，视网膜ON信息通道而非OFF通道参与了青蛙OKN慢相的产生。
