一项评估已故捐赠者疾病传播风险的试点项目：纽约器官捐赠者网络传染病工作组。

A pilot program to evaluate deceased donor disease transmission risk: the New York Organ Donor Network Infectious Disease Working Group.

作者信息

Pellett Madan Rebecca, Delli Carpini Kristin, Huprikar Shirish, Lerner Harvey, Patel Gopi, Ratner Lloyd E, Goldstein Michael J, Herold Betsy C

机构信息

1 Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY. 2 New York Organ Donor Network, New York, NY. 3 Department of Medicine, Mount Sinai School of Medicine, New York, NY. 4 Department of Surgery, Columbia University Medical Center, New York, NY. 5 Recanati/Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY. 6 Address correspondence to: Rebecca Pellett Madan, M.D., M.S., Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer 702D, Bronx, NY 10461.

出版信息

Transplantation. 2014 Oct 27;98(8):909-15. doi: 10.1097/TP.0000000000000152.

DOI:10.1097/TP.0000000000000152

PMID:24879385

Abstract

BACKGROUND

Recent cases of donor-derived infections raise the question of how best to screen donors without excessive restriction of the donor pool.

METHODS

The New York Organ Donor Network (NYODN) established an Infectious Diseases Working Group (IDWG) in 2008, which established an on-call schedule of voluntary transplant infectious disease physicians to provide remote evaluations for donors at increased risk for disease transmission.

RESULTS

Data were reviewed from 40 available IDWG evaluations from 2008 to 2011. Eighteen cases (45%) were considered to be at unacceptable risk for infection transmission. Sixteen of these cases were excluded from donation secondary to IDWG recommendation; there was limited recipient center interest in the remaining two cases. Approximately 22 (55%) cases were categorized by the IDWG as acceptable, with 14 proceeding to recovery of 49 organs. IDWG physician recommendations were conveyed to recipient centers, and screening guidelines for donors were revised based on the IDWG experiences.

CONCLUSION

Establishment of a donation service area disease transmission evaluation service is a valuable program for donor screening and may promote dissemination of more detailed donor information to recipient centers.

摘要

背景

近期供体源性感染病例引发了一个问题，即如何在不过度限制供体库的情况下，以最佳方式筛选供体。

方法

纽约器官捐赠网络（NYODN）于2008年成立了传染病工作组（IDWG），该工作组制定了一份由志愿移植传染病医生组成的值班时间表，以便为疾病传播风险增加的供体提供远程评估。

结果

对2008年至2011年期间40次可用的IDWG评估数据进行了审查。18例（45%）被认为存在不可接受的感染传播风险。其中16例因IDWG的建议而被排除在捐赠之外；其余两例受体中心的兴趣有限。IDWG将约22例（55%）归类为可接受，其中14例成功获取了49个器官。IDWG医生的建议传达给了受体中心，并根据IDWG的经验修订了供体筛选指南。